Dyschondrosteosis and Madelung Wrist Deformity

This is the self-help group or support group for people with dyschondrosteosis ( DCS )and/or Madelung Wrist Deformity ( MWD ). That is a permanent broken wrist appearance for the Madelung and foreshortened arms or legs in dyschondrosteosis. It came about because of some research I did on a very obscure medical condition. One person in my family was noticeably affected but as no one else apparently affected it was not considered to be genetic.
This file updated September 2014
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Many years ago (1980s) I tried to do some medical research on another condition but was defeated as I have no medical knowledge. I spent some time at the Boldrewood Medical Library facility in Southampton but got nowhere really. The problem is you need a bit of medical knowledge to even start. This has all changed with the internet. In effect there is ,via the medical search engines such as Medline and OMIM ,what I call a reverse medical dictionary. By this I mean from starting with non medical or marginal medical terms or descriptions you can get to precise medical terminology; the reverse of a medical dictionary.
The condition of interest recently, had been diagnosed but decades ago ,when this noticeably affected person was seen by a Harley St ,London, specialist. The diagnosis was misheard/ mis-remembered by one person as Mendel something and by someone else as Mendelsohn something and by someone else as something rickets. In December 1998 putting mendel* as a keyword in Medline got nowhere. The condition affects the ulna and radius bones so putting keywords in Medline and OMIM of radius AND ulna AND rickets returned a lot of hits. Reading all the returned abstracts in conjunction with a standard medical dictionary (to understand and distinguish distal from proximal and supination from pronation etc) two medium level medical terms looked promising. These were radio-ulnar (affecting both bones) and dysplasia (disordered development ). Putting these two words back in the system returned a few dozen abstracts. About half of the original articles referred to by these abstracts were on the shelves of the medical library at Southampton General Hospital. I didn't even know this library existed till now nor whether it is exceptional in allowing access to the responsible general public. A few related, highly specific terms emerged in these articles and abstracts namely; dyschondrosteosis,mesomelia ( form of semi dwarfism) and Madelung (probably the original misheard diagnosis). Madelung wrist deformity leads to a mechanically poor joint between wrist and ulna because the wrist bones are asymmetric and cause a bunching on the ulna side of the wrist throwing the head of the ulna forwards or sometimes more rarely reverseward so it looks like a ganglion at the end of the ulna (there are alternative explanations for the development of MWD). In effect it leads to a permanent partial dislocation (subluxation) of the wrist. Putting these three terms in OMIM and Medline and checking the articles another week in the medical library confirmed that this was indeed the condition and that it was genetic and very rare, affecting only about 1 in 100,000 to 1 in 800,000 of the general population.The clincher was reference to the Madelung wrist deformity which no one in my family were aware of but with hindsight is now obvious with everyone in different generations. This internet procedure is probably applicable to other technical disciplines say geology or law if there is a suitable thematic search engine for the relevant technical journals . In 2013 medical search engine FindZebra , http://findzebra.compute.dtu.dk/ turned up on the scene



I would be interested in making contact with anyone familiar with the linked medical conditions :-dyschondrosteosis,mesomelic dwarfism and Madelung wrist deformity all a sub-set of the general group of skeletal dysplasias. I could find medical references on the net but nothing about the more sociological aspects of these conditions so have placed this page into the internet realm.
On the male side there can be serious family problems concerning "questionable" paternity; how could a father 6 foot or so have a son 5 foot or a father of 5 foot 2 have a son who is 6 foot 2, a sort of perceived cuckoo in the nest syndrome.
This genetic quirk can happen spontaneously or where there is offspring of a consanguineous relationship i.e. father/daughter or brother/sister or cousins. This is the biblical "sins of the father" territory. It can cause family schisms where some of the family is aware of the family secret, others suspect and some have no idea at all, the common thread is that it is a total taboo and no one will discuss it at all within or outside the family. Some people just wish this syndrome would just disappear if they ignore it and others wish to find out what is going on. Obviously the former will not find their way to this file. It has to be remembered that the proportion of children adopted who are of incestuous origin is high and consequently proportion of adoptees with conditions like MWD or DCS is also higher than background levels. 6 of the people contacting this group have MWD or DCS stemming from people who were adopted, beyond that is unknown, just informed speculation. Higher than the general level of adoption within the population. Illegitamacy is difficult enough to handle within a family but very few families would be able to knowingly raise a child of incestuous origin - it is one taboo too far, they are likely to be placed for adoption.
So far, eight people out of the people who have contacted me, had not got a medical diagnosis before finding this file - two put "wrist deformity" , someone else "gymnasts wrist deformity " and someone else something like the words (wrist deformity limited wrist movement short arms ) as a keyword/phrase in a search engine. All the others have had the tight medical keywords of madelung or "leri weill" or dyschondrosteosis to put in search engines. Another potential problem can be that some people would have been put on a course of growth hormone treatment after being diagnosed. In the early days this was derived from cadavers with ,unknowingly, possible contamination by prions or whatever leading to a "Sword of Damocles" of CJD hanging over them.
It was only in the 1970s it would appear that the researchers put a genetic link to these ,at first sight, unrelated effects. Other medical terms for dyschondrosteosis or similar looking or related conditions are/were manus valga, carpus curvus, congenital dislocation of the wrist, late rickets of the wrist, progressive subluxation of the wrist, progressive idiopathic curvature of the radius, adolescent club-hand, carpo-cyphose, carpo-cyfose,carpocyphose, cubitolisthesis, manus furca, gabelhand, radius brevior , dyschondroplasia of the inferior radial epiphysis, osteochondrosteosis, adolescent rickets, carpal dysmorphosis, carpal kyphosis, carpoficiosis, dyschondrosis, radius brevior, radius parvus, Leri Weill Syndrome, DCO, LWS, LWD, radiovolar bayonet deformity, chondrosteodysplasia, MD Madelung Deformity , DCS (dyschondrosteosis). It is my conjecture that MWD and DCS result from some sort of genetically controlled switch. Not a case of lack of growth hormone but something switching off the uptake in the chondrite areas of some bones. Resulting in a lack of growth in that area of one end of that particular bone but not the other ,similarly either end of the matching bone pair eg Ulna/Radius and Tibia /Fibula may grow/not grow causing curving of the longer bone while growing.
Some relevant keywords for researching Madelung are lucency, pyramidalization/pyramidalisation,triangularization/triangularisation.
For anyone of a sensitive nature all the listed references at the end of this file do not carry reference to some of the more gross deformations and fatal conditions that a keyword search on Medline and Omim medical search engines inevitably turn up. It would appear there was a flurry of publications in the 1960s and 70s and little since until the 90s when geneticists became intrigued.
Seven sets of examples of the family genetics ,first two taken from journal source 6 at the end of the file
Firstly for a patient with MWD only (no DCS) 3 generations of 21 related people were medically checked and she was the only one with MWD; her parents were without MWD and her 4 daughters showed no MWD. She was one of 11 siblings 6 male and 5 female ,none of the others with MWD. 2 of her non-affected sisters had 2 non-affected daughters each.
Secondly the family tree of 5 generations of someone diagnosed with DCS,Nf=Normal female,m=male,D=DCS,++ = union,-- = sibling, ? = not checked. Fourth generation affected male was the index patient who incidentally proved to be the first recorded case of male to male inheritance in 100 years of the literature on DCS. The 'trees' below are intended for a font with equal spaced letters if it is to be read correctly.
    Nm  Df
     |++|
Df--Df--Dm--Nm--Dm  Nf
                 |++|
            Nm  Df--Nm
             |++|
      Nf--Df--Dm--Nm
   ?++|   |++?
      Nf  Df
The above would seem to be fairly representative of how DCS propagates. It was not clear in this journal but my interpretation is that in this example anyone diagnosed with DCS would have been someone only showing MWD as well cases of DCS and cases of DCS + MWD. I have used generally in this file the interpretation of DCS as being someone showing mesomelia as the defining trait and for the situation of MWD someone having an obvious wrist disorder but no obvious mesomelic foreshortening of forearm or lower leg.
Third example M=MWD only with no mesomelia. It is from one of this self help group with permission to publish but no identifying detail.
 
        Q    Z
        Dm  Nf
         |++|
         A  B
    Nf  Mm--Df  Nm
     |++|    |++|
    A1  A2   B1  B2
    Dm--Mf   Mf--Mf


The genetics in the above family probably show meiotic recombination between PARs (pseudoautosomal regions) ie the telomeric extremeties of both X and Y chromosomes.
There are two possible explanations for the LWD / DCS to cause LWD in all the family members male and female with either normal stature/Madelung or short/DCS.
Possibility 1:
LWD starts in mother of children A and B (and not in the father). Then there is only a recombination necessary between X and Y of A to son A2.
Possibility 2:
If LWD started in father Q of children A and B, then there are two recombinations necessary:
If the Q had SHOX mutation in X-chromosome
once from Q to A
once from A to daughter A1

or
If Q had SHOX mutation in Y-chromosome
once from Q to B
once from A to daugther A1

Fourth example in Italy from reference 4
        Nm  Df
         |++|
    Nm  Df--Df  Nm
     |++|    |++|
      Nf   Nm--Nm--Nm--Nm


Fifth example from Poland from reference 2
     Nf--Nf--Dm  Nf
              |++|
         Nm  Df--Nm--Nm--Nm
          |++|
     Nf  Nm--Dm  Nf
      |++|    |++| 
Nm--Nm--Nf    Nm--Df--Nm--Dm--Df-twins-Df


Sixth examples taken from 8 French families from reference 17
Circles - female, blocks - male,black - affected, open - unaffected
 French families
Seventh examples taken from 7 UK and Swiss families in reference 16
 UK and Swiss families
To summarise the genetics that would appear to emerge from these above medical family trees and the family histories of people contacting this site. It would appear if you have isolated MWD with no history of MWD or DCS in any other of your family then it looks as though you will not pass on MWD to any offspring. If you have MWD or DCS with another family member with MWD or DCS then there is a high probability of passing on either or both MWD or DCS to any offspring. If you are an unaffected sibling of an affected person then a low probability of passing on MWD or DCS. Unfortunately, generally speaking, in the medical-genetic studies the offspring of unaffected siblings are not studied. Whether you are an affected male or female ,with family history of the conditions, then you can pass on the genetic predisposition. I have not had medical confirmation of the above statement and have not seen it stated in any medical journal ,it is just a consensus view with no authority. Female offspring tend to be 4 times more likely than male offspring to display the condition and have a more marked version. The factor of 4 is the number repeatedly stated in the medical literature. On reading the contributory stories in these files, the proportion would appear to be much greater than 4 to 1. As far as having a serious form of the conditions then perhaps more like 30 to 1 female to male. This is probably due to oestrogens exerting a maturational effect on the skeletal tissues that are susceptible to premature fusion of growth plates in conjunction with SHOX deficiency where normal SHOX sufficiency would counteract the maturing effect of oestrogens.
The following comment I have revised in the light of the experience of people who have contacted me with MWD (see personal stories below). It was my conjecture that dyschondrosteosis is a medical curiosity with little or no requirement for surgical or other interventions and that since the eighties there has been no research money available for what may be considered a cosmetic condition. There has been renewed interest recently because genetically it has an unpredictable amount of expression ie the degree of affect in related individuals although genetically a dominant inheritance.
A practical manifestation of the Madelung wrist deformity is the following. Ask the average person to sit on an upright dining chair with their arms out-stretched with the web of the hands (between thumb and first finger) resting on the thighs and they would have their thumbs against the inner thighs. This position ,long term, would be uncomfortable for someone with the Madelung wrist and would tend to adopt a position with the thumbs to the outside with ulnas uppermost, see link to picture of Louise Robey below.
It is highly likely that Jimi Hendrix (1942-1970) the guitarist had this condition (see later note concerning his son in Sweden). His performance at Woodstock ,on film, shows the characteristic protruding ulna etc. The book Jimi Hendrix :the man, the music, the memorabilia page 3 and page 67 by Caesar Glebbeck show his wrists, page 8 has a picture as a pre-teenager with the characteristic uneven long bone development which balances up by puberty; the same picture is on p20 of Jimi Hendrix Gypsey by Henry Shapiro.Also p160 and p708 in this book shows his wrists well. The Life of Jimi Hendrix by David Henderson informs us that Jimi was 5foot 11 inches and his father Al 5foot 2inches which is consistent. There was speculation as to who his father was probably principally from this height disparity. A quote from page 28 "Jimi......much taller than his father ,although not quite six foot himself. Jimi's arms draped down almost to his knees. Sometimes his father would stop work and come and stand by his side comparing arm lengths in jest" I am not a guitarist but I can see how this wrist condition would allow Jimi to play his guitar in his inimitable fashion. He played left handed with a right handed guitar re-strung which meant the pick-up control switches and knobs were under his hand. Because of the Madelung offset angle between hand and arm he could control these switches with part of his palm while picking the strings. In the reverse set-up a right-handed ,normal wristed, player using a re-strung left hand guitar would also have the controls under his palm but he would not easily be able to manipulate them while playing.
 jimi hendrix
Close-up of Jimi Hendrix's right wrist with nobble of ulna marked with 4 red circles, his left wrist is probably more representive.
 jimi hendrix right wrist
Another close-up ,head of Radius marked R and Ulna marked U with the "pivot" point of the wrist well set back and under the Ulna-head ,in shadow under the ulna rather than distally to the ulna-head. The line (green) of the small finger along the edge of the palm should normally line up with the head of the ulna. The normal hand position relative to the wrist should be more like the red line in otherwise the same bent down angle of the hand. Looking at the back of his palm the small finger side is dropped down relative to the thumb side; this is what I have termed the Madelung offset. Another illustrative pic of one hand at least
http://www.photographicimage.com/prodimg/RK-007-wm.jpg

 jimi hendrix right wrist 2
Unfortunately (maybe consciously like a number of people with MWD) Jimi Hendrix not only usually wore long sleeves and wide wrist-bands but sometimes frilly cuffs.. Pictures taken from the Caesar Glebbeck book mentioned above. Recently I saw a piece of film/tape of Jimi performing Voodoo Chile in 1969 on BBC tv "The Lulu Show". At the very end he does his picking with the teeth routine and showed the ulna side of his right wrist spectacularly well. I would estimate the unforced Madelung offset to be more that 30mm. His left wrist had his usual wide wrist "bracelet" marked with a red "B". I recorded onto video tape and photographed off the tv screen and scanned in . This low resolution version is the best I can do at the moment from the black and white TV image. His right elbow is at the left hand bottom corner of the TV screen and left forearm and hand at the right of the picture.
 jimi hendrix Madelung offset
The serious joggle between the overlaid red circles is the unmistakable offset. The view is taken from underneath his vertical forearm (shadow showing the ulna)and the underside of his guitar, the fingers of his right arm at the white neck of the guitar. At this angle you would normally be looking at the edge of someone's right hand and perhaps palm but because of the Madelung offset you see the top of his hand and knuckles, his thumb would be around the neck of the guitar. Video now on youtube 3m 48 seconds into the 4 minute clip.
Jimi Hendrix - Voodoo Chile live
The following has rather too many ifs for my liking but is an interesting exercise. If Hendrix had MWD and if the facial appearance of a broad/flat/depressed/wide nasal bridge goes with MWD/DCS then Jimi Hendrix had wide upper nose and from family photos it was his father Al who had this wide nose. Then of the paternal grandparents his grandmother Nora Rose Moore had the wide nasal bridge. She was by family legend the grand-daughter of a Cherokee princess. I find it surprising that with all the millions of people who have watched Jimi Hendrix on film I seem to be the only one to have "diagnosed" him to have MWD. I agreed to send a copy of my tape of this part of the Jimi Hendrix performance to a published medic, of international repute outside the UK, researching into MWD. There would have been no problem giving a negative diagnosis ie ,say, JH has not got MWD. All I got was a definite, repeated, no-comment. I took that as a tacit acknowledgement that JH probably had MWD. A practising medical professional could in no way give a diagnosis, remote and second hand, to a dead person especially considering that MWD is a genetic condition and there are living relatives of Jimi Hendrix.
And a comment by email to someone in this group from Prof. Peter Scambler (author to reference 15 below ), Molecular Medicine Unit, Institute of Child Health, London, after seeing this file; "I had come across the idea that the late great Jimi Hendrix had Madelung, and that accounted for some of his ability with a guitar".
Looking at film of his father, Al Hendrix, he probably had Cubitus Valgus and also, reportedly, was born with six fingers on each hand. Looking at film of his purported brother, Leon Hendrix, I saw no semblance of DCS or MWD (as part of a decades long inheritance legal dispute there was a DNA profile check concerning whether they were brothers, but the results were withheld) . No six fingers seen either but a dactylectomy as a youngster would be likely in such circumstances .
It would be interesting to see if Jimi's son James Henrik Daniel Sundquist Hendrix shows any symptoms. Assuming this is a genuine profile at 1.81m then MWD but not DCS it would seem
Myspace profile by/of Jimi Hendrix's son
" Anyone who has ever met me in person had no doubt that I am his real son. (I even have a rare http://www.divdev.fsnet.co.uk/dysch.htm joint condition the same) "
Is this a world first, remote diagnosis of a very rare medical condition via picture evidence 30 years after death ? Of all the strange coincidences one of the people with MWD who has contacted this group had lived next door to Al Hendrix, neither knowing they may have had the same syndrome because of its different manifestations. JH invalided out of the military , according to which story you read, homosexual tendencies, parachute jump ankle or back injury, not injuries to wrists, but joint-weakness likely and proneness to such injuries is likely.
Another possible "diagnosis" of someone else in the public eye. In 1999 the Earl of Burford caused a rumpus in the House of Lords in London. In an interview at that time in passing he mentioned his wife had odd wrists. He had noticed it on first seeing her "porcelain wrists" as there was apparently the same sort of wonky wrists in his own family. Or as reported in the Daily Telegraph newspaper on 28 Oct 1999
Note - You have to now subscribe to the archive of this newspaper
" The couple met in Beverly Hills at a lecture by Lord Burford on his pet theory that Edward de Vere, the 17th Earl of Oxford, was actually the author of the plays attributed to William Shakespeare. She said: "After we met, he started writing me 16-page letters that were just beautiful. I fell in love with his writing and he fell in love with my wrists, or so he says." "
His wife was an actress called Louise Robey. According to the Canadian Screen Guild she has appeared in 3 movies and a TV series.
1. Raw Deal with Arnold Schwarzenegger in 1986 (a small role).
2. The Money Pit with Tom Hanks in 1986 (named in the credits as title music composer rather than the non-speaking role).
3. Play Nice, in 1992.
4. Micki Foster in the TV version of Friday the 13th series in 1987 in which she was the leading lady.
I hired a copy of Raw Deal. Louise Robey (in the credits as Robey playing part "Lamanski's girl" ) has a one minute role playing a gangster's moll. She is robbed of jewelry in a stretch limo by Arnold Schwarzenegger 26 minutes, about 1/3 way, into the film. A close up shows Louise removing an earring. Her right wrist shows the protruding knobble of the ulna bone at the wrist that is a characteristic appearance of Madelung. Even if her wrist is the result of trauma rather than congenital Madelung Wrist Deformity or other anomaly it is useful to have moving film showing someone with the appearance of this deformity rather than medical research still photographs. The following is a picture of her with a posture adopted that would be typical of someone with MWD, rather a photogenic pic of the countess rather than a pic of me adopting the same pose.

 Loise Robey

or here, Picture of Louise Robey a less cluttered but mirror image version.

One of the most subtley enigmatic pics on the net. This picture shows someone in a pose that looks unnatural or uncomfortable or even impossible but is quite comfortable for someone with the non-painful form of MWD (see above reference to sitting on a dining chair). Note the forward prominence of her right ulna. I have asked friends with normal wrists if they notice anything odd about this picture and then asked them to strike-up this pose. Almost all of them thought there was something odd about her hands, that is right hand with fingers and palm touching thigh, fingers straight across, not at an angle, and arm straight at the elbow, two thought it was a computer manipulated image. They either could not adopt this pose or it was very uncomfortable and a strain. This otherwise awkward looking posture is very familiar to me in my own family and may even be another pointer or signature of MWD.
From ref 34 below
For people with LWD but not MWD it would seem there is a high probability of the following short 4th metacarpal and disappearing knuckles. 1) For the right hand to start with. Turn tips of all fingers under so that looking down at the hand you see back of hand and the first segments only of the fingers. The first metacarpal is your thumb and 5th is the small finger. The following is called Albright's sign. With a ruler join the farthest point of the observed 5th to similar point of the 4th .Then if normal fingers the ruler would pass outside of remaining fingers. With small 4th metacarpal the ruler would cross over the 3rd metacarpal. 2) curl round fingers further to make a fist. Again observing now just the back of the hand normally the knuckles would have a sinusoidal up and down profile. With Leri-Weill this ripple is often absent or much reduced.
As for rarity of Madelung Wrist Deformity or DCS may remain undiagnosed because it is often misdiagnosed as arthritis, Carpal Tunnel Syndrome, etc or just not diagnosed . From a clinical geneticist working on the SHOX gene associated with DCS and MWD I contacted via one of her journal articles: "I agree that it is difficult to find the incidence of dyschondrosteosis in any references- there is one of 3-7 per million (Atlas of Skeletal Dysplasias) but in my opinion it is likely to be more common than this as it can be mild and so is not always diagnosed maybe 1/100,000- but this is only an estimate".
Confirmed the following from the British Library copy of this book :- According to Adrian E. Flatt, The Care of Congenital Hand Anomalies (St Louis: The C. V. Mosby Co.,1977;page 50) 37 cases of congenital MWD in 1,476 patients with congenital hand malformations (1.7 per cent of general hand malformations) and 1 to 2 per cent of live births with hand malformations so about 1 in 4,000 of the general population of Iowa USA of the 1970s.
For comparison purposes the population in 1997 of USA was 260 million, Canada 29m,UK 58m,Holland 16m, Sweden 9m, Italy 57m, Australia 18m, New Zealand 4m. Tasmania 0.47m,Northern Ireland 1.6m,Norway 4.3m ,Chile 14m,Peru 23m,Israel 5.5m, Denmark 5.3m, Brazil 156m, Poland 39m ,Mexico 93m.
The following is not rigorous statistically but gives a flavour of the rarity. From replies (up to the revision date at the head of this file) to this group (principally), concerning just numbers of DCS and/or MWD affected and/or diagnosed persons including affected family members is :
Holland (22 people) would indicate less rare than 1 in 800,000.
N. Ireland (3 people) the rarity in the general population probably less than 1 in 750,000.
The most valid assessment due to the large proportion of internet users must be the USA, 211 people referred to on these files so rarity less than 1 in 1.2 million. Another possible interpretation for the USA rarity is it is a nation of much more ethnic diversity ie less inbred.
In the UK 129 people, so rarity less than 1 in 500,000 of the population
In Australia 47 people (plus the Sydney 12 ? ) so rarity less than 1 in 400,000 ( or perhaps 1 in 300,000 )
Canada 30 people, so rarity less than 1 in 1.2 million
New Zealand 6 people, so less than 1 in 700,000
12 people in Sweden so less than 1 in 800,000
8 in Denmark, so less than 1 in 650,000
3 in Israel so 1 in 1.8 million
1 in Norway
2 people in Chile
1 in Peru
1 in Poland
1 in Brazil
3 in Mexico
1 in Spain
NB the Dutch and N. Ireland figures include numbers from medical sources so there is perhaps justification for saying these are more valid figures. Then include the number of people totally unaware of the diagnosis and a figure of 1 in 100,000 looks likely. A point to be aware of ; of all the people making contact via this site not a single case of anyone ,knowingly, being related to anyone else in this group.

A few personal stories

The following personal stories would not have been possible but for the internet and global "whole text" search engines putting everyone in contact. About 132 people ( as of end of 2005 ), some isolated, and some with a familial genetic history so perhaps 400 or so people in total via family links. If anyone would like to contact the group please e-mail me ,my contact details are after the personal histories. No spam gets past me, the email addresses stay within the group and no names or email addresses released to the internet other than my own.



But first a few easy to perform tests for Madelung Wrist Deformity. I know from reading the medical research papers that it is very difficult to understand the terminology relating to these tests so I have put them in simple language. First test I will call for convenience N1 plus R for right and L for left. A simple test for Madelung wrist deformity (but not necessarily unique to MWD and I hasten to add I've not had qualified medical opinion on the following). For inspecting right wrist (N1R) place the thumb of the left hand on the wrist end of the right ulna. Place the first finger of the left hand against the section of the right palm nearest to the ulna. Then with a "squeezing" action (with firmness that would probably break a hen's egg if applied to the weakest diameter of an egg) the misalignment should substantially reduce but immediately spring back on releasing the pressure. Make an estimate in mm how much misalignment there is. Repeat for the other hand (N1L). MWD is usually bilateral ie both wrists but maybe more pronounced in one wrist than the other. See person C below who has the "bayonet" form of MWD and my N tests do not apply with this variant of MWD. There may be clicking of wrists on moving. Hold forearn horizontal in front of chest with thumb towards you. With hand sloping downwards initially, rotate the forearm until the ulna is uppormost. Or return to the horizintal forearm position and with hand hanging loose , vertically down, raise the hand to as vertical as possible. I've put 3 photos of this description in the following. This is not the "bayonet" form although a relative of mine does have the "bayonet form" .I've not seen such a sequence in any of the medical research literature and gives something nearer a "dynamic" view of what is going on. Overlaid on the first photo is a rough idea of where the ulna lies. The first image is of hand and forearm resting on a flat surface in a natural state. The displacement between the two blue markers is about 21mm. The ruler is marked in centimetres.
 wrist - natural state
The blue markers remain in the same position for the next two images. It is not possible to conduct the N test as described above and photograph at the same time so have approximated by placing a small block under the ulna side of the palm and pushed the forearm down. This gives a minimum displacement of about 7mm
 wrist - minimum displacement
For the maximum displacement holding the fingers down on the flat surface and forcing the forearm upwards.
 wrist - maximum displacement
This shows a displacement of about 23mm. So from minimum to maximum a movement of 16mm. Actually doing the N test applying force directly over the displacement is more like 20mm.
The following 2 tests have been verified by a practising orthopedic specialist but for convenience I have called P1 and P2
Test P1
For testing right wrist (P1R) you must hold your elbow with your left hand. Turn you right thumb from facing right to facing left. Somebody with madelung can't make a 180 degree turn.
Test P2
Next you can test the upward movement by moving your hand, palm up,(and holding your arm still) up and down. Someone with a healthy wrist has a range of about 180 degrees (from down to up). Someone with Madelung hasn't, they have less than 180 degrees.

Of course proper medical diagnosis requires X-rays being taken and analysed by a physician familiar with the condition or at least familiar with reading X-rays for which the wrist is naturally rather variable from person to person.


In the following list of people those marked [ CL ] are in the e-mail circulation list. I am the moderator / gatekeeper so no spam etc gets passed on. This is a closed group with no one's full name or e-mail address released except my own.

Myself,Nigel,England [ CL ] MWD
I am in 40s and can't honestly say my wrists are a problem and only doing this research did I realise I had a medically discernible condition. Although someone in my family was diagnosed in the 1960s with the more obvious DCS there was nothing to suggest then it was hereditary and no family genetic counselling . I never realised my wonkey wrists had the same genetic origin and being benign there was no need to seek medical advice . Writing wordy essays at school meant my wrists ached after a while perhaps this a contributory reason for me preferring maths and physics. "growing pains" leading to disturbed sleep may have been more than normal. As long as I lift heavy weights in an appropriate manner (lifting with the end of the forearm rather than my hand under the object) and don't subject them to shock loading ( eg not competing in tug-of-war and not pushing a car with stopped engine to bump start etc) .I have not had any problem in adulthood only once totally dislocating my wrist but jumping straight back again, when I was about 25. This was unloading a 50 Kg bag of fertilizer from a lorry, the plastic bag slipped and instead of letting it drop I tried grabbing it with one wrist at an awkward angle. As a teenager I broke my wrists on 3 separate occasions but it was dismissed as boys will be boys falling off things and an inherent weakness was never diagnosed. The 3 occasions were falling off a bike, getting forearm wedged under a child's playground swing and while crank starting an agricultural engine that backfired. All situations where anyone could have broken a wrist. The perplexed radiographer tryig to understand why my good wrist looked as broken in the x-rays as my broken wrist. I never broke a leg or arm it was only ever wrists. I have only self-diagnosed in the last few years (1998-1999). My GP (doctor) was most impressed he actually jumped out of his seat to manipulate my wrists: he had never seen or heard of the condition - I demonstrated MWD to him as I was about to leave his surgery having visited on another matter. Walking through doorways I often knocked this exposed area of the ulna against the door-frame also wearing a watch it had to lie on forearm above this knobble. If I get the angles and pressures just right using the other hand I can make the radius side of my right wrist sublux into the "bayonet " form. It springs back after releasing the pressure unlike the permanent bayonet form . I have always been cautious of handshakes. The origins for handshaking is as a sign of non-hostility because originally it meant your hand could not be on the hilt of your sword if it was clasping someone else's hand. Unfortunately too many people go to exaggerated shaking etc which for someone with MWD is aggravating. [Incidentally chinking of glasses has a similar origin. As a check against poison in someone's glass - the chinking in pewter type vessels guaranteed the contents of one cup would slurp into the other cup.]
 pre-adolescent self
Fifth digit clinodactyly to a minor degree. It is just possible that hearing anomalies are associated with DCS and MWD there are references to this in the journal articles eg ref. (50 below ). Someone else in my family had reduced hearing capacity from early middle age. I went the other way in teens and twenties I was susceptible to high frequency noise well above the normal hearing range ie technically between 15 KHertz and 40KHertz. In those days a lot of shops etc had ultrasonic intruder detector systems on their premises now superseded with PIR detectors. For technical reasons those ultrasonic systems had the transmitters active all the time and only the receivers switched off day time so I had to duck and dive to avoid them as they were usually placed at head height. MWD/DCS is an irregularity in bone development; hearing relies on the smallest bones in the body so there could well be a connection. Someone else in this group has separately experienced this phenomenom. Routine hospital hearing tests would seem to only go up to 8KHz which is nowhere near the ultrasonic range, so presumably the reference here is the only reference to it in association with DCS/LWD/MWD.
I would appear to have a fibula/knee anamoly, with either leg but right most prominent. Bend leg at knee then angle upwards the foot and twist the foot to direction of centre of body. The top of the fibula bone on the outside side of the body protrudes outwards. Another trait that seems to go along parallel with DCS is facial characteristic of wide nasal bridge ,ie the bony part of the nose rather than the fleshy part being wider than normal.
Demonstrating MWD half-broken wrists in a social environment is quite some party-trick - it can make some people come over quite nauseous. On the development history. Here is a photograph of me as a pre-teen that except for the trite observation that I am white and Jimi was black could be the same as this preteen picture of Jimi Hendrix taken Seattle 1946 and appeared on a 1993, vol 7, No 4, cover of the Japan version of Esquire magazine.
Pre-teen Jimi Hendrix
Both pictures show someone in short trousers with knees at different heights with one leg angled and each arm maybe different in length. The shoulders are canted perhaps 20 degrees off horizontal, twisted and bent limb bones and splayed feet all very rickets like. In all we look like we were assembled, cobbled together, on the Friday afternoon shift while drunk. By age 15 these asymmetric growth rates had balanced up to give an evenly balanced stance of 6ft 3in. There was just one long term effect - poor foot angle when walking, leading to fast wear of the outer rear edge of the heels of shoes. Also some clinodactyly in a couple of toes. fourth metacarpal, leading to overlap under the third, when pressured, in walking causing problems. Test results for myself:- N1L a displacement of about 8mm and N1R about 20mm P1L 150 degrees P1R 150 degrees P2L 80 degrees P2R 90 degrees

P in Holland (in email contact with) [ CL ] DCS
Well I've got dyschondrosteosis. It's also called Leri Weill syndrome. I'm in my 20s (in 2000, female)and one of my wrists has been operated. They've put a piece of my hipbone in it with a piece of metal on top with 7 screws in order to keep my wrist from moving cause it hurt to much. I live in Holland and there are 4 other families in Holland (each with 2 patients, I'm the only one in my family). I'm the first person with dyschondrosteosis in my family. . The dyschondrosteosis is most visible in my arms (wrists) and mildly in my legs. My left wrist is the worst and gave me a lot of pain. The pain was caused by the fact that my wrist was permanently dislocated and my muscles had to work very hard to keep everything together. Test results P1R 90 degrees P1L 20 degrees The doctors are very quick in diagnosing Madelung but they're not looking further. Madelung itself is not heriditary and it's easy to determine if someone has dyschondrosteosis with Madelung or that the Madelung is a birthdefect or caused by a accident. In most cases a simple X-ray of the legs is conclusive. If "A" wants to I can give her information, especially because we're practically the same age and I've had my wrist stiffened (arthrodeses).
Update Oct, 2005
Just a quick update on my own situation: they're going to remove the metal fusion plate from my left wrist on December 20th because it is causing zwelling and such and such.

From I in Canada (in email contact with) [ CL ] MWD
This year (2000) I just discovered that I (female) have Madelung's Deformity. I have had trouble with both wrists ever since I can remember and I am anxious to write to someone with the same deformity. I am also in my forties. When I was a young child my wrists would become painful especially writeing, playing piano, knitting or typing. My mum just thought that I was saying that because I didn't want to do these things. I always had protruding wrists (outside area) so I knew then that my wrists were different than any one else. About twenty-six years ago when I was pregnant with my first child I starting experiencing numbness and tingling in both hands especially in bed at night or when I would hold something for a period of time (my left hand was the worst). I was told that this was common with some pregnancies with the extra water retention in my system. I had four children and had the same ailment throughout. Five years ago my Family doctor sent me to see a RHEUMATOLOGIST who said that I had Carpal Tunnel Syndrome and I had various tests done, was on different medications and had to wear wrist braces going to bed at night . Last year (1999) I experienced a lot of pain in my right wrist and the bone was protruding more than usual. I'm right-handed but I couldn't use my right hand as it was so painful and the pain shot down to my little finger and up to my elbow. I had to go to the hospital for some extensive testing and the doctor there told me that I didn't have Carpal Tunnel but he never told me what was wrong. I went back to the Rheumatologist and he told me that I had some kind of birth defect and left it at that. Meanwhile, I was in agony and sometimes cried with the pain so I went back to my Family doctor and he referred me to a ORTHOPAEDIC SURGEON. This Surgeon did a full history and testings before he would let me leave his office and was able to tell me straight away that I had Madelung's Deformity. He told me that it was very RARE and GENETIC and that he would only operate as the last resort as it was quite a big operation. He was more interested in getting the pain under control so I had a Cortisone shot which took a few weeks to take affect and also put me on an anti-inflammatory and pain killer called CELEBREX (what is mainly for arthritis which I don't have). The deformity affects the Ulna and Volar in both of my wrists although the deformity is now worse in my right wrist as the outer bone seems to have moved more towards the middle of the wrist and my hand tends to turn more to the right now. Test results P1L 110 degrees P1R 150 degrees

K in Tasmania (in e-mail contact) [ CL ] MWD
A couple of weeks ago (in 2000,female) I too was diagnoed with Madalung's deformity (aged 21). I was at the specialist at my local hospital when I found out. Luckly there were student doctors there so i was told a bit about the condition. But the only treatment i was told about was an operation which they won't do unless it gets much worse. so i went looking on the internet for some not medical treatments for the pain in my wrists and for some more information when i found your site. So what i am asking is, can you pass on any information that you recieve. and do you know of any treatments or things that i can do to make my live easier. All the information i have found on the net went over my head, there were lots of technical stuff that i didn't understand. The main thing that irritates me about madelung's is that my family doctor had never heard of it, let alone knew how to treat it. and the medical books she has had very little info in them. I was told I had MWD in July this year, I found out because the pain in my left wrist had never really left since spraining it aroud 4 years ago and then it proceeded to get worst since the begining of the year. The Dr at the local youth health center sent me for xrays basicly to make me happy because he couldn't see anything wrong but could see that I was in pain. After the xrays came back with a V dispalacement, he decided that I too would need to see an Ortho Dr. The younger doctors in the Ortho Department at the Hospital told me that there was no reason they could see for the pain and it was one of those things that I will have to live with. But they thought they would check with the old!!! Dr to see what he thought. The young Dr briefed the old one and as soon as he walked in said that I had this MWD. Because my local hospital is a teaching hospital, he went and explined it to me and the Student Doctors. He said the people with MWD are prone to sprains. To explain the way the deformity affects the wrist, He also said that I can play on the monkey bars, But never to do a hand stand, because this will make it worse. Now if i even knock my wrist I bandage it up over night or for a couple of days for protection so that it doesn't get any worse. Basically why go to the doctor and pay them to tell you to wrap it up and go easy on it.

C in the USA (in e-mail contact)
I have Madelung's Deformity. I'm 46 years old and 5ft 10in I read some info and letters on your website. I've had trouble all my life with wrist pain, the worst in my late teens and early 20s and now again just recently in the last 6 months. I've used moist heat (hydroculator) , ice, anti-inflammatories and since April of 2000 I go to a massage therapist at least twice a month. The massage therapy has given me the most relief. I've played piano since age 8, concert organ and pipe organ since age 11, crochet, needle point, and do secretarial work for the last 13 years (writing this in 2000). I was tested for Carpal Tunnel in April 2000, which results were negative. The wrists braces the doctor gave me to wear while waiting for the test date actually made my wrists weaker. I wanted to write in case someone can benefit from my input. I was diagnosed with Madelung's Deformity only this last April. When I was growing up my parents and I just figured that I had weak wrists. My symptoms have included weakness in the wrists all my life, this last year - dropping things like jars of jelly, milk cartons etc. (have to use both hands to lift anything) , I've also had numerous wrist sprains since I was about 18 years old and a real bad spell where my wrists hurt non stop for about 2 years about age 19 - 20. I wear ace wraps off and on and when I played tennis even as a child, wore ace wraps. My wrists bones on both wrists stick way out.... thru my life many people have asked me, "Wow, did you break your wrist or something?" ------(by e-m i mentioned she probably had the "bayonet wrist" variant If someone looks at you side on when your standing up and arms down and palms facing backwards. The hands are stepped backwards from the line of the forearm (joggled) like the way a bayonet is fixed to a rifle off centre so the blade does not interfere with the path of a bullet.)------- Yes! That's exactly it. And I also can not straighten my arm at the elbow if my palm is flat against a wall at shoulder level {probably Cubitus Valgus}. I didn't mention that the hand specialist who diagnosed me in April wanted to do surgery. I told him that i'd rather live with it. I do go to a Massage Therapist every other week and she works my neck, upper back, arms and wrist real well. I've been taking Glucosamine Complex and I'll let you know if it helps. Was suggested to me by a friend who went to a holistic doctor. Also doing an exercise where you squeeze your thumb to fore finger and count to five and then squeeze your other fingers the same and then stretch out the whole hand and do the other hand the same. So far the theraputic massages every other week have helped the most and I can go for days now without any pain at all in one or both wrists.

R in the USA
While browsing the web I found your web page and I must say that its quite nice to see. I have Madelung's deformity and it can be quite painful, especially with repetitive movement such as writing, typing, etc. I would really like to get in contact with other people with the same condition. I have been to a wrist specialist who diagnosed my condition. Unfortunately, the treatment is basically "do whatever doesn't hurt." So I would really like to be in contact with other people with the same condition.

T in the UK
just found your address on web, what is your interest in madelung as i have suffered as long as i can remember with said deformity. i am female and i am 45

From D in the USA in e-mail contact with. [ CL ] DCS+MWD
I (female) was happy to have found your website! I have two daughters and one son. My daughters are 11 and 12 1/2, they have both recently been diagnosed with Madelung's Deformity. They will be participating in a research study on Madelung's here close to home. Have you found anything else that is typically found to be wrong in someone with Madelung's Deformity? The Dr. believes the girls also have Leri-Weill Dyschondrosteosis, and that my husband has Leri-Weill also, although he doesn't have Madelung's Deformity. I would like to find out how rare this is, but they can't seem to give an answer. The Dr. doing the research said he believes it's much more common than people origially thought, but not able to give me any real numbers. Are you also short statured? My daughters are very short statured. Do you know if you have radial head displasia (RHD)? Both of my daughters have it. The Doctor said that all people with the radial head displasia typically have Madelung's Deformity, but not everyone with Madelung's has the RHD. I would love to hear from you. Followup Nov 2000
We were at the hospital again today, from E's fall a couple of weeks ago, for her to be checked again. Today they checked her legs, they said it is common for girls with this to have very big calves. E does, but my oldest, S, does not. They made a special brace for E as she has very large forearms and a normal brace off the shelf does not fit her right. I asked the Dr. what the chances are, if she has pain now at 11, what the odds are that she will have pain the rest of her life, he says no, but that doesn't seem to be the case from most of the others on the mailing list, I've met through your website. I don't want my girls to have to suffer with pain their whole life! I believe I already told you, but we are participating in two studies on MWD. Followup Sept 2001
Just thought I would update you all on my daughters and their Madelungs. S is doing well, not due to see the Dr. again till next year. She is starting to have pain when she does to much writing, she is 13. This scares me, as she has never had pain before and it is just now "developing". The doctors won't do anything for her, as she has what they call a "mild" or "less severe" case of Madelungs. E, had surgery on her left wrist in April. It is much more severe case of Madelungs. She had such severe pain before the surgery, and after had no pain whatsoever. We were so thrilled.....until 2 weeks ago when she started having severe pain in the same wrist (left) she had surgery on. She is already scheduled to have surgery on the right arm in October, but now we have to consider another surgery on the left. After her surgery in April she was in a long arm cast for 6 weeks, which wasn't to bad on her left arm, as she is right handed. When we get the right arm done she is very concerned about having that long arm cast on her right arm and not being able to use it. The doctors have even mentioned doing both arms in October, but we (my husband and I) are going to let them know that we want to get the left fixed then schedule the right. It also scares me that the doctors keep telling me that when their growth plate closes there is no reason to believe they will have any pain at all, but the letters I see from most of you says that you do have pain as you get older. The growth plate should close around 15 or so. I love the hospital here in -, they have been really great, and as I have told some of you, we participated in a study, that I believe is still ongoing in Philadelphia, PA, about Madelungs. We found out that it is genetic and that it usually affects that SHOX gene, which has some mutation.

From A in the USA in e-m contact with [ CL ] MWD
Hi, My name is A. I am 24 and live in the US. I was just diagnosed (2000,female ) with Madelung's deformity and found your web site. I just wanted to tell you how informative it was, I wasn't able to find a whole lot of info online. I am a Registered Nurse and had never heard of Madelung's until I was sitting in the doctor's office with what I thought was a strained wrist. My left wrist is the most symptomatic, and it has bothered me since I can remember. I never thought anything about it though. I am dominant on my right, so left sided weakness never affected me until now. I am feeling very frustrated because my doctor told me I was going to have to live with the pain, that none of the available surgeries would benefit me. Of all things he thought wrist fusion may work later on, but for me that isn't an option. I have found most of my information from medical textbooks and professional journals, but I would be interested in any information that you may have. Thanks.

C2 in the USA in e-m contact with [ CL ] MWD
Hello, my name is C, .... i also have madelungs deformity. i had pain in my wrist since i was about 15 years old. but if i ever had pain before i think i just ignored it. but over a few years its became alot worse. im 18 now (in 2000,female), im getting surgery done on my arm/wrist. i go to the doctor in about a week to get a CT scan (cat scan) so that he can get a better look at my bones. then after that appointment i go in front of many doctors here in to see what the best kind of surgury for me would be. So i think this is actually a very good way of solving the problem. My mom also realized that she has it and so did her aunt. so it seems to be quite a problem in my family. Well i just thought that i would share my thoughts with you and my problem. i really like your website it had a lot of interesting information on there. thanks alot!!

From B in the USA in em contact with [ CL ] MWD
I have a 15 year-old daughter (2000) who was recently diagnosed with Madelung's Deformity. It is in her right wrist and she is right-handed. The doctor has advised fusing her wrist. Has anyone had this done and do they have any regrets? I worry about the loss of motion in her wrist, but she is really wanting the surgery. I would feel better if I could hear from others who have had this done.

From A in Holland (father) in e-mail contact with [ CL ] DCS+MWD
This morning (2000) we searched the web for information about Madelung's Deformity. We're very glad we've found your notes. Our daughter "A" (15 years old) is known to have Madelung's Deformity for about 1 year.The last few months the pain has become worse,for example at school she has trouble with carrying and lifting her books. Both wrists have the deformity,left gives most of the problems. Last year we visited a doctor(who made the diagnosis) and he told us that there were only 5 other people in Holland with the same problem. We have no idea how to go further and are looking for information that can help us along. Reading your pages we saw that you have (email) contact with " P in Holland". If possible we would like to make contact with him to gain information about the possibilities about treatment in Holland etc.So maybe you can give us his email address But also your other contacts have our attention. We feel free(if it's oke) to contact you again.Thank you for your attention,hope to hear from you soon. "A" is the only one known with the Madelung's Deformity in our family. About a year ago she started complaining about her wrists. We consulted a doctor(orthopaedist) in our local hospital. He made some X-rays and told us he'd never saw anything like it before. Unfortunately he only made X-rays of both wrists,so he didn't notice the curving of the radius.The next morning he called us and told us he'd found similar photo's in his book known as Madelung's deformity.He made an appointment for us with a professor called Mr. D. I think this will be the same professor P visited! He X-rayed the whole skeleton and gave us the diagnosis Dyschondrosteosis and Madelung wrist deformity."A" is only 1.55 meters tall. Her legs (tibia/fibula) are short in comparison with the rest of the body. He told us that no treatment was necessary at that point.At that time she had no pain and it lasted well for a whole time.At the moment the pain is becoming worse and she has difficulties at school carrying her bag as we already wrote. So we're looking for more information about possibilities and treatment.

End of year 2000


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Start of year 2009




From M3 in the UK , (in e-mail contact) MWD
Hello, my name is M_ (female). I am 14 and from england. I have been diagnosed with mwd in my right wrist. It has become so bad and so painful that i now cannot write. To get through my school career i have to type out my work on a laptop. For my english project i need to research an intrest in my life, and i chose to research my deformity. I was wondering if i could join the wonky wrist club. The doctors have told me that i will have to wait until ive stopped growing before they can operate on my wrist, and that might take years, do you know of any alternate ways of correction?

From A in Canada ,joined 2003, followup May 2009
Unfortunately, my MWD is gotten worse throughout the years therefore I'm having reconstructive surgery (partial fusion) on May 26, 09. I have faith that I have found the best upper limb extremety Doctor in Canada. If anyone is interested in more info pls feel free to contact me.

From M4 in the UK , (in e-mail contact) [ CL ] MWD
I am pleased that I found this site, I went to the doctors today and now know what is wrong with me, I have madelungs! Im 33 female, 5ft and have always know there is a problem, in my early teens I had a lot of visits to the hospital and nothing seemed to become of it, it was never really spoken about within my family, always seen as not important, on visiting the doctors today the condition is on my medical file and was identified when I was around 10 years old, cant remember why nothing else was done or why i, always had abit of mild pain, but now my wrists are now starting to cause me pain when im carrying to much. and I am now concerned that they are going to become worse as I get older, both my wrist are twisted and have bowed short forearms, reading the site has given me so much information that I did not know, and it is a comfort that im not the only one, ive always ignored comments and people looking at me, I do block it out and put off dealing with it, I come across as this doesn’t bother me, but get upset in pivate and never talk about it. As reguards to my family, my cousin, who male, has been diagnosed of it, but doesn't really give him any trouble, has both wrists the same as mine but not as noticeable, and I also have another cousin ( not diagnosed )who is male and very short, so maybe some connection there. I am now going to the hospital next month and learning to deal with this!! Thanks to reading information on MWD I have a lot more clear understanding

From D in New Zealand ( in e-mail contact) [ CL ] MWD
Hi, my 12 year old daughter has been visiting a paediatritian for 4 years because I was concerned with her height (she has been sitting on the 3rd percentile on her growth chart despite my husband being 6'2 and me 5'4). A wrist x-ray for bone age found her bone age to be 2 years behind her actual age and also found her to have Madelung deformity in both wrists. I asked the orthopaedic surgeon if her short stature was related to her Madelung deformity and he said no. I then found your site and discovered they could be very related. Are there any measurements I could take without x-rays to check fore-arm and lower leg proportions to present this possibility to her specialist? Thank you for the wealth of information.

From G3 in the USA (in e-mail contact) [ CL ] MWD
I (female) discovered your website through our local doctor. I'm living and working on _ [ a tiny atoll in the Pacific ,600 miles from any other atoll or any other island, betwen Hawaii and Guam ]. She has been very interested in my wrists and short arms. I always thought the deformity was called Madeline's deformity. She spent a couple of days researching and found your website. I was born in Long Beach, CA U.S.A. I have a severe case of MWD. My sister also has it as did my father. His mother had it and her father had it. We're not sure how far back in the family history it goes. A few years ago it was very painful but I've been pain free for a few years now. I've had several orthopedic surgeons wanting to do surgery for comsmetic purposes but decided surgery was too much of a risk. The looks of my wrists don't really bother me much anymore and when people ask what happened I just tell them I left them out in the rain and they warped and they usually laugh. I think it's kind of cool that it's very rare and I share this defomity with someone famous.

From D in the UK (in e-mail contact) [ CL ] MWD
Hi there, my daughter has just been diagnosed with Madelung deformity. She is 13, and has been having pain in her wrists on and off for around 6 months. Today we saw Professor _ at Southampton General Hospital, and got the diagnosis. We have been told to think about surgery to correct it, and I would love to hear from anyone who has had surgery, and those that opted out of it, so we can make an informed choice on how to proceed. Nobody else in the family has any signs or symptoms of MWD at all. The consultant who my daughter saw yesterday told us that its very rare, and that he sees maybe 1 case a year. She does cope remarkably well, and only seems to struggle with some sports, especially volley ball, and some daily activities are difficult when the pain is bad. Thanks for setting up this group, there are no others for MWD, not that I can find anyway.

From ?? in ?? (in e-mail contact) MWD
I am 53 with what I believe to be MWD in my right arm however have never been diagnosed. I have two daughters, my youngest daughter diagnosed with MWD at age 14 - she is now 19. Her arms are short as well as 4th and 5th didgits, her 2 knuckles are half back on her hand. Her forearms are bowed as well. She does have very long legs, most of the length in the legs is in her upper leg. She is 5'11. My other daughter may have normal height but not sure the lower portion of her leg is normal as she has very large calf's. I'm concerned after reading your article that this could be passed further. I have no knowledge of family history...... as both parents are dead 20+ years.

From C8 in the USA , (in e-mail contact) [ CL ] MWD
My name is C_, Kansas, and I am 22 years old. I have had unusual pain in my wrist my whole life. I have always had the abnormal looking ulna. I have went to the Dr. several times with the same response: xrays are normal. I started going to school to become a court reporting and started having sever pain in both my wrist. I went to the Dr. and again my xrays were normal. After a year of putting up with this pain my fingers started tingling and would often go numb. I decided I was going to a specialist. After seeing the xrays and the Dr.'s jaw dropping response, I was scared. The Dr. never told me that day what I had. He called me the next day (after looking it up) to tell me I had Madelung's. He doesn't feel comfortable treating it. He sent me to a neurologist and the results were a mild form of carpal tunnel. He is referring me to another Dr. but he is unfamiliar with this deformity also. He told me I will have to change my career plans and that this could be a lifelong issue for me. They are now wanting me to see a Dr. in St. Louis, MO. I have researched this Dr. and he is not too familiar either. I was wondering if there is a Dr. that is more familiar with this deformity. If I have to travel, I might as well go to someone who knows more about the subject. Thank you so much for this site. It has informed me more than any other site. It is very helpful to hear positive and negative feedback. I have my xrays from a year ago and I will be getting my most recent ones if you would like me to send you a copy. My family has not been diagnosed with this. My grandma does show signs of dwarfism. She is about 4'7" and at her tallest was 4'11" and my cousin is 5'2". Her daughter has been diagnosed with Turners Syndrome. I am unsure if they are related but the doctor I went to the other day said they have similarities in the bone deformity and may have came from the same gene. I am not sure though. Thank you so much.

From J in Canada , (in e-mail contact) [ CL ] MWD
I live in Toronto, ontario, canada My 13 yr old daughter was diagnosed with Madelung's deformity about 2 yrs ago. She had banged her arm at school, i took her to our local hospital emergency dept. The took x-rays, the doctor said it looked like she had a dislocated growth plate in her wrist. He told us to comeback the next day and he would give her a mild sedative and manipulate the growth plate back into place.When we came back the next day the doctor told us that he had shown her x-ray to the head of the dept, the dept head told him that it was not a disloctaion but in fact madelung's deformity, he himself had heard of it but never seen it. We were advised that it most cases do not present any problems. My daughter experiences mild to moderate discomfort and continuously complains of this.She has one wrist that is more promenant the the other , i also think that it affects her self esteem. I am not aware of anyone else in our family with it, but we have a large family, relatives that we have little contact with. Does anyone have any idea how many people are inflicted with this.

From K2 in the UK , (in e-mail contact) [ CL ] MWD
I read with interest your site as there doesn't seem to be much information on this subject! I am 37 years old, normal height (5 ft 6) and was diagnosed with madelungs some 10 years ago through having an MRI scan as doctors were a bit baffled. I have got by over the last few years but lately having pain and hardly any movement in one wrist. I am seeing my GP this week to try and start the process again. Could anyone tell me more about surgery available? I'm not aware of anyone else in our family having this although my mum has weak wrists. I did miscarry a baby girl at 16 weeks and when tests carried out it showed 'edwards' syndrome', she had no lower arms - never thought of it before but could have been linked possibly. I am hoping to see my GP with MRI scans this week to get the ball rolling. I am just concerned that at 37 years having trouble which may get worse.

From C9 in the USA , (in e-mail contact) [ CL ] MWD
My name is C, and my son T_ (age 20) has Madelung's. He was diagnosed at age 13. I noted on FB that you are trying to create a list of those that have MD. Please add my son to your list. We are trying to find as much information as we can about it. My son is the only of our four children that exhibits the symptons. My other son is nearly six feet tall, has long arms and legs. My son with MWD is just over five feet, with short limbs. One of our daughters also is of normal height, but does exhibit some of the symptoms in her ankles (wide, misshaped).

From A in the UK , (in e-mail contact) [ CL ] MWD
I was recently diagnosed with Madelung wrist 'deformity' after an accident on holiday required xrays. I dont really know what it means, and theres so much information on the internet I was getting a bit freaked out. I wonder if my form is down to displaysia, as I was born with hip displaysia, or wether its completely irrelevant? My sister also has a rare spinal condition so it would seem that we do have a congenital problem with our bone structure. Does it actually mean anything? the doctors have told me nothing, I only found out by chance when i had xrays on my feet yesterday that requires surgery.
2010
From M in New Zealand , (in e-mail contact) [ CL ] MWD
I was diagnosed with MWD in 2003 when I was 13. Now due to various injuries (Im clumsy and fall alot) I have quite bad pain. I was wondering if you knew the best treatment? I have researched about as much as I can but all of the details are to technical for my understanding. And also, what are your veiws on just getting a wrist replacement? Thank you for the site! Very helpful!

From S7 in the UK , Scotland (in e-mail contact) [ CL ] MWD
hello im a female 39 have a severe form of madelungs and shortening of the arms..also club feet when younger...have had surgery on my right wrist but has made it weaker would love to find out more especilally from sufferers..I FEEL IM THE ONLY PERSON IN SCOTLAND TO HAVE THIS... i would like to no how severe..how rare..long term effects etc etc .. i can supply photos if needed.. my mum had a slight raised bone in wrist but no shorting of the arm my 14 year old daughter has same as my mum..tho her hands are weak.. as you can imagine lots and lots of questions and depressing thoughts some times .. has not done my confidence any good..
From J13 in the USA , (in e-mail contact) [ CL ] MWD
My 14 year old daughter R was just diagnosed with MWD in both wrists, although the pain has only been in her right wrist as of now. This is the 3rd doctor we have seen so I guess we are lucky to have been diagnosed this quickly. Now I am very unsure of what to expect or what could be done to help her at this stage, as she is still growing. The doctor can't really answer my questions or recommend treatment because he hasn't seen cases of this. How can I find doctors with experience with this in the USA? As of now I have not been able to find any other family members with this condition and I also have a 16 yr old daughter that does not have this. But I'm still in the process of asking extended family members on both sides of the family. Right now this is all very new to us.
From N2 in the UK , MWD and DCS
I cannot tell you how relieved I was to find your website. Although I haven't officially been diagnosed with Madelung's, I am fairly sure that this is the condition that's plagued me for the past 13 years at least (I'm 25 now). I decided to research my symptoms online, and was totally surprised to find that there are other people out there with arms and wrists like mine - thank you for bringing this to my attention, I was starting to feel very alone. I have short arms, around 3/4 the length they should be. My left arm is "classic" Madelung's (as far as I understand it), with the ulnar bump and the "step down" from my arm to the back of my hand. My right arm is different - the radius has grown faster than the ulna, causing the hand to be misaligned with the arm, so the hand tilts in the direction of my little finger. Both arms are "bowed", and my humerus is also shorter than normal. I also have the "disappearing knuckles" I have read about. I'm not sure whether my short arms mean that I have Dyschondrosteosis as well as Madelung's deformity? My legs appear normal. I'm 5ft2. My mum has slightly short arms (not as short as mine), has the wrist "bump" and is around 5ft. My dad has normal wrists, and is around 5ft10. It was first noticed I had "funny" arms when I was around 12 years old. I sprained my right arm playing sport at school, and when the pain didn't subside for months, and my deformity got progressively worse, i went to my GP. I was referred to the "burns and plastics" (!) dept of my local hospital, as my GP thought it was an aesthetic problem. I was eventually transferred to the orthopaedics section. The consultant orthopaedic surgeon didn't have a clue what was wrong with me either, but did eventually operate on my right arm. A triangle was cut out of the radius, and the bones fixed back together with a metal plate, so straightening the arm. Despite this being an experiment for the surgeon, I have to say it worked - my arm is definitely less bent and I hardly ever feel any pain. But I do have a long scar covering 2/3 the length of my forearm, which isn't the best. I also lack self confidence, and really hate the appearance of my arms. I would definitely like to be genetically tested to see if I do in fact have MWD - does the NHS offer this in the UK?
From L4 in the USA , (in e-mail contact) [ CL ] MWD
I was diagnosed with MWD when I was 13. I was having problems doing pushups in Physical Education and went to a dr. They first did xrays and asked if I had ever been abused because it looked like both of my wrists has been broken. My mom worked at a hospital and her ortho surgon diagnosed me. Over the years pain come and goes but the one thing that has helped is sleeping with wrist braces on. The pain decreases significantly. Hope that maybe it may help some others since the Dr that diagnosed me is the only one that's ever had a clue! No one in my family has the appearence of MWD the dr that diagnosed me said it was weird that I am the only one that has it. It's only in my wrists. I had xrays on my ankles as well and they are fine I'm 5'9. I was told that surgery could help or may decrease my range of motion so it was advised against. I only have about a 30% backwards motion.
From L4 in the Canada , (in e-mail contact) [ CL ] MWD
My name is l_ and ive been diagnosed with Madelung since i was 14. it's getting worse. Could someone from Toronto Canada help me find a doctor that will do something? im in so much pain. I am looking for ppl who have done the surgery and the results. Sorry my messages are so short and lack information, i'm jst in so much pain.

From M7 in the USA , (in e-mail contact) [ CL ] MWD
Hi I'm M_ from the US. I was recently diagnosted with possible Madelung Wrist Disorder. Survived my teens without problems. Early 20s I developed a painful dislocated looking wrist. Went to doctor was told I had tendonitis after a few minutes with doctor. No xrays ordered. Sent home in a brace. Off and on for over 12 years wrist got swollen and humpy looking. Now at 39 I hairline fractured my left wrist. Told it wasn't serious enough to brace, splint or cast. Sent home on work restriction. Went for second opinion and was told basically there was nothing that could be done. I may have a mild form of Madelung Wrist Disorder. Finding info is like driving, blindfolded in the pitch dark with no lights on. So I jokingly asked the doctor if I was a rare deformed person and he said Yes. But I'll tell your husband that you had a broken wrist that was never set. Now me and my left wrist which I have taken to affectionately calling Quasimoto are looking for answers or even a doctor to get rid of the painful hump

From T2 in the USA , (in e-mail contact) MWD
I will start with a short introductory of myself and then see if it goes through. My name is T_ and I live in USA with MWD. I was diagnosed with dyschondrosteosis when I was twelve and had 2 extensive surgerys on them at theage of 12 and 13 (both wrist). I am now 31 and the pain came back within the last 2 weeks. Not sure what to do from here as I do not have the time or energy to devote to another surgery

2011

From J14 in the USA , (in e-mail contact) [CL] MWD+DCS
I have Leri weill syndrome osteodphy/madelung deformity I have this and have been suffering if you can say with it for as long as I can remember please contact me. I have a real diagnosis. My daughter do and my self, my dad's side of the family have multiple people with the apperance of it as well. But not a diagnose. My eldest daughter and I have a diagnoses. My middle child has questionable trace features of the bone disease. My yungest chikd I dobt has any thing but time will tell.

From J3 in the UK , (in e-mail contact) MWD + DCS
I saw your link "wonky arms" My daughter has been diagnosed,she also has the bowed leg symptom which is more of an immediate worry.She has abnormal shaping in her arms but the doctors here in Newcastle , England are more worried about her legs and she has been offered surgery(what type we are not sure yet) Do you speak to parents of children with the condition in both legs and arms ? Have any of them had children who have under gone surgery ? And any tips on how you cope with the constant stares of people when your out and about without losing your temper ?!

From S4 in Australia , (in e-mail contact) [ CL ] MWD+DCS
I have dyschondrosteosis. I am 31 years of age, 148cm tall. I stopped growing at 12 years of age. My back is long and my legs and arms quite short due to madelungs. It was diagnosed in me first then we noticed my entire family has it too to a lesser degree. My son is 3 years of age and I'm watching him like a hawk for signs of madelungs. Though I've had operations as a child on my arms I have chronic pain in my wrists for which i take panadol and nurofen. How many people in my extended family has symptoms ? My 2 sisters. My mum and her 2 sisters. My eldest aunt has 1 daughter TG and 1 son NG both have thick wrists and ankles with some bowing. TG has 1 daughter who has stopped growing at 12 years of age, she is 146 cm. She has thick wrists and ankles but less severe bowing and seems more proportioned in her size. NG has two sons both young 10 and 12 years old but no signs of madelungs, both long and lanky. My youngest aunt has 1 daughter only 9 years old, but no signs or symptoms. My mum's mum is smaller than me and she is the tallest of her 7 sisters all who appear to have severe bowing of wrists and lower legs. I am more than happy to talk to anyone about my experience with madelungs. I have had 6 operations in total, I've recently spoken with a geneticist, I deal with society's negative attitude towards small statured people almost everyday, I have dealt with depression in the process of coming to accept myself as I am, with my little wonkie arms. So if anyone wants to chat about it I'd love hear other experiences, maybe help someone else along the way, perhaps make a few friends who look like me.

From S5 in the UK , (in e-mail contact) [ CL ] MWD
I have had the weird rare MWD. Not as severe as some of the photos on Google sites ( thank goodness ) My fore arms are approx 2 inches short for my height of 5ft 5 inches. I have recently hurt my right wrist, by pulling my holiday suitcase in and out the car. I am note sure if a wrist brace/ splint/bandage or or wrist exercises will ease the pain ? Do you know the best remedy to ease the wrist pain ? I am taking Ibruprfen pain killlers at the mo. I have not been back to the hospital specialist since I was 13/ 14 That was in 1980 at Westminster children's hosp ( since closed down 20 yrs ago ) I declined the rare corrective op when I was 16, as I didn't want to be a Guinea pig back then in 1983 age 16. Maybe I should go back to hosp for new x rays, as I was told in 1980 , aged 13 that I may ? get Arthritis at an earlier than average age ? My main prob is buying clothes, the sleeves are too long, I have to alter the sleeves / jackets sleeves by inches ! £££ cos I can't sew lol and receiving change / coins in a shop, is a bit tricky at times, having to cup my hand/ fingers to make receiving coins ok or the coins roll straight on the floor ! It's easier to collect coins if I pull my elbow in. I do prefer 3/4 length tops, re no alterations at the tailors/ dry cleaners . It looks like I have previously broken my wrists , to look at them, but a lot people don't notice until I show them my limited rotation and the lump/ bone being a bit bigger than normal people. and I can't do press up's. I was fine until age 13, puberty I guess, bone growth. No Dwarfism in my family, I am just one of the rare 2 percent of people with MWD, google said 2 percent and females more prone to it than men. I remember when I first noticed my wrist bumps aged 13, my mum mentioned it to the GP when my sister ( who is just 8 mths and 3 wks older than me, as I was 7 wks prem baby, I used to think my dodgy wrists were because I was 7 wks premature and my sister born so close to me, I was convieved too quick lol, my dad a fast worker , blush ) My sister was taken to the GP with a belly ache. The GP referred me to Westminster children's hosp, I saw a Mr _ top Orthopaedic man there. On my second visit, after the x rays ....He told me " Young lady, we have had to go down in to our hospital dungeons/ archives, to find info. on yr wrists, it's Madelungs wrist deformity, it is very rare, it is like winning the football pools; But less fortunate" I did chuckle to myself. On my 3rd visit a month later ? I was asked if I could let other Orthopaedic docs/ specialists, from all over the UK, if they could meet me at Westminster hospital to see my MWD, it was like freak show lol, they all queued up with note pads and had a feel of my wrists and asked me questions about any pain and mobility probs etc, and if any bone probs in my family No bone probs at all, just me ! ) I live a normal life with my MWD, i had even forgotten the name of it until I asked my GP last year ! I could only remember Madelines syndrome wrist deformity, which is the wrong name lol, no wonder I couldn't find any info. on google until I got the CORRECT name from my GP file. Just a shame my suit case saga this week, has made my right wrist ache ! apart from that and having probs receiving coins/ change in shops, and a few other minor probs that I have learnt to live with, as my wrists have always had just a third ? of the normal rotation. I can carry heavy shopping bags , I just make sure I don't grab them too fast and wrench my wrists.

From K9 in the USA, (in e-mail contact) [ CL ] MWD
Hello, I live in the US in the midwest, southern Illinois,I am a female age 47. I have read quite a bit of the information from other mwd patients. I discovered that my daughter had mwd when she was 9. She had two small surgeries at age 10, our pediatric orthopedic surgeon in St.Louis Mo consulted a dr in Australia and discovered a procedure where they open the wrist and remove a ligament that seems to be tightly wrapped around the radius , then taking fatty tissue from her arm about 6 inches away from her armpit and placing it in the growth plate , they said to keep the growth plate open longer . You can find information in the Journal of Hand Surgery (British Volume, 1992) 17B: 401-407 The doctors are _ and _ from the Royal Childrens Hospital, Brisbane, Australia. Unfortunatley for her it did not help much due to the fact that her wrists were so bad , at age 14 when the growth plates were closed they did reconstructive surgery. She had quite extensive surgery severing one of her ulna bones in three places , placing a steel plate and screws in place where the bowing was so bad and placing an external fixator on her arm for about 6 months. Then moving on to the second arm. At age 16 she had completed both arms. My niece had the procedure with the ligament and fatty tissue at age 10 and has not had problems at all. My daughter was the first one in my family to be diagnosed with mwd but definitley not the last. I have it, two of my sisters havev it, one neice has it , my father had a form of it, his mother had it, 3 of his sisters had it as well , that is a total of 10 that we know of. My father was 5"6" , the rest are 4'9' - 5"3", that being the tallest and that is my daughter. Wow quite a bit. I have always had trouble with my wrists as far as I can remember, but latley(the past couple of years) I have had alot of trouble with my hips, I am in pain all of the time with this. I am on anti inflamatory medication that does not seem to be helping. I wondered if anyone else is having any issues with this?

From N3 in the UK, (in e-mail contact) [ CL ] MWD
I am 28 years old female and have self diagnosed myself with MWD. I do feel the left is worse, i have been to see specialists however had very little feedback and have never been diagnosed, I am a very active person, personal trainer, so every sport under the sun even kickboxing and i am a sports massage therapist also which i do full time. I am starting to suffer with my wrists and have always pretty much tried to forget about them. I am being referred to a specialist and would love to have surgery however am not sure what the success rate are and if the surgeon will even have a clue what to do with my wrists when he sees them it does worry me about passing this onto my children one day and would upset me greatly if i know this was going to be the case, however that is life. It's quite amazing to actually find other people who have the same condition. it seems that no one else has the same condition as me in my family. I have tried to find out and genetically there is no link at the moment. I will do my home work on the surgeon and would not consider having any surgery unless the surgeon had performed similar or the same before with wonderful results.

2012

From S8 in the UK , Lancashire (in e-mail contact) [ CL ] DCS & MWD
I am trying to research Dyschondrosteosis madelung wrist deformity as I am thought to suffer from both conditions. I was referred to the paediatrician at around 8 years old because of my short stature but they could never diagnose why i was so small, they then did a full body xray and still nothing. At age 17 i became pregnant and was then referred to dr _ at manchester childrens hosptial who advised she thought i was suffering from Dyschondrosteosis and madelung. However, she advised she could not check this as they had lost my old xrays and couldnt xray me at the time as i was pregnant. I have never really thought about it since however I now have a daughter aged 6 and was advised that Dyschondrosteosis passed onto girl more predominantly so have asked my gp to be referred to a paedeatrician which she now has an appointment to see. I have tried to find more information on this condition for myself as I now do seem to be suffering from pain in my wrists which i has never occured previously. I would appreciate and advice or information you could give me regarding this as I am currently not under any consultant for myself.

From J15 in the USA , (in e-mail contact) [ CL ] MWD
I ran across your research today and wanted to contact you for people in the state of Washington (USA) with Madelung's deformity. According to my mother she knew that I had this when I was born because my paternal grandmother had it. I did look at some of the pictures on your site but mine is much more pronounced than the pictures shown. I have not had a lot of problems (other than occasional pain) from this until lately (I am almost 68 years old now). I would like to know what others with this problem are doing for the pain. When I was 14 years old I tore the cartilage in my knee and when the doctor examined me he said that the deformity was also present in the way my knees were configured. Do others have this problem too? In my family my paternal grandmother who had madelungs died before I was mature enough to ask her any questions about her experience with it. My father who just recently died did not know much about it and all his siblings are deceased

From C5 in the UK , (in e-mail contact) [ CL ] MWD
My 8yr old daughter has MWD and I don't know what pain killers would be best suited.

From D2 in Australia , (in e-mail contact) [ CL ] MWD
Hi I have madelungs in both my wrist..I found out at age 8 Im now 25 and its to the point I cant move my right wrist.. Drs here in Australia have never heard of it well the drs Ive seen.I have three kids and Im in so much pain.. Noone else in my family have it they have carpal tunnel n roomatoid arthritis sorry cant spell them

From P2 in the USA, CT (in e-mail contact) [ CL ] MWD
I just read some of your very long article about Madelung's deformity and other problems. I was diagnosed with Madelung's deformity when I was about 14 years old. I am now 72 and still suffer from problems especialy when playing tennis. I just bought a neoprene splint for my right hand because of a problem with my thumb. It is helping my thumb and my wrist. I have had to endure pain in both of my wrists my whole life but I generally do whatever I can with some restrictions. I have never been offered any help by any doctor. I have not encountered any health professional who knows anything about Madelung's except the physician who diagnosed it orginally. Thank you for researching the subject so much. No one in my family has it. I am short 4' 11'' but I have a brother 6' 1' and the rest of my family is average or tall. The proportions of my legs and arms is normal. I hope this helps you in your research. How rare is this disorder?

From S9 in the UK, (in e-mail contact) [ CL ] MWD +DCS
I'm a 28 woman from north Hampshire. I had noticed (and people had commented about) my strange looking wrists... my dad has the same and recently had an x-ray where the doctors were fascinated! He is about 5'5 and I am 4'10. I would happily send photos. My forearms are very short, with a pronounced 'lump' at the wrist and limited movement. My torso seems normal size but calves are short/bowed. I came across yours website and other articles and was very interested in what I found.


From S in Ireland, (in e-mail contact) [ CL ] DCS
I (female) found your website very interesting as I was diagnosed with dyschondrosteosis when I was 7 years old, I'm now 45. I had a lot of wrist pains and was sent to the hospital in the 70s where, after much research, they told me I had this problem. All my family were tested and we found out that my father also has this condition. Since then I've found very few doctors who know anything about it. I've never been offered surgery and have never thought of having it. I'm only 4"10 and I do get pains in all my joints periodically but I tend to deal with it. I am English but live in Ireland.
For anyone in the circulation list, after reading this current file, and realise they have not been circulated. If they re-contact me stating their old email address and their [ CL ] code letter/number/country I can re-instate them. People with aol.com email addresses will have to contact someone else (non AOL ) in the list to get them to relay these circulated emails as AOL bounce Bcc , probably due to them falsely interpretting as spam and rejecting. Maybe this problem: Title "Mailings blocked" on http://technology.guardian.co.uk/weekly/story/0,,1580155,00.html
As of Oct 2005 all 14 AOL addresses removed from circulation/update emails. The properly constituted anti-spam/virus system would pass them all through with falsely tagging of the title with *** SPAM *** , *** VIRUS *** or whatever. Leaving just the amended title, sender's address, and first 3 lines if they must do any deleting/disarming. Then the recipients can simply set a filter to divert into a probable-spam folder and periodically check the titles themselves for false inclusions, due to too many non-dictionary technical words or whatever, before deleting the lot. Hotmail is now rejecting emails, UK based NTL / ntlworld contacts are likely to be the next subgroup to be so excluded.

The wrist condition was recognised and then published by Herr Madelung in 1878 ( 17 years before X-ray images were invented) and later was named after him.

********************

Otto Wilhelm Madelung - Die spontane Subluxation der Hand nach vorne. Verhandlungen d. deutschen Gesellschaft fur Chirurgie 7:259-276,1878 ( The Spontaneous Forward Subluxation of the Hand- Proceedings of the German Association of Surgeons 1878 ) . Also in Arch.Klin. Chir 1878;23:395-412
I tried getting a copy of this journal article from a medical archive institute in Freiburg, Germany but their series of this journal go back to 1879. May 2002 I contacted Prof Dr Gudrun Rappold at Heidelberg and she forwarded on a copy of his article to me. The following is a rough transcript of that article . There are errors especially confusion between "e" and "c" as almost indistinguishable in the printed typeface plus usual mis-keyings. It not only contains archaic medical terms but is written in the German of one and a quarter centuries ago.

O W Madelung 1878 Journal Article ( <> German )

This 1878 article ,for the moment ,crudely translated into something resembling English but not as she is spoke. The gist of the paper is there. When both myself ,and a German speaking friend ,can find time, we will tidy up the translation. I am not a medic and know no German so it is surprising there is anything intelligible in this translation. I find sections of the technical medical journals on these topics to be fairly impenetrable even in English. It is an amalgam of a few online machine translations and use of a large German to English dictionary and a German medical dictionary at Boldrewood Medical Library. Untranslated words are in italics.
O W Madelung 1878 Journal Article ( <> English )
A recent return to OW Madelung and his work.
Part of article Journal of Hand Surgery (American) / Vol 31A, No 2, February 2006
*********************
And now the first publication of what later became known as Leri-Weill Syndrome. Just 4 weeks to get a copy of this 1929 French journal presumably from France via the British Library and that despite my journal reference to this article had Vol 53 not Vol 35.
Note may still be some uncorrected mistranscribed letters c / e / : i / l : t / f
Text only , the pictures were too indistinct to copy

Leri & Weill Journal Article,1929 ( <> French )

Bulletins et Memoires de la Societe Medicale des Hopitaux de Paris.
Une Affection Congenitale et Symetrique de Developpement Osseux: la Dyschondrosteosa
By Leri, A And Weill,J
Vol 35, 20 Dec 1929, pp 1491 to 1494
Later citations refer to this article, same page numbers and year, as Vol 53
Journal name abbreviated to Bull. Soc. Med. Hop. Paris
The following is my translation ,NB I have no knowledge of French or Medicine so read with that proviso. It is result of machine translation and use of a number of French Medical dictionaries. Should anyone, with knowledge of French, spot any errors distorting the meaning, please contact me
Leri & Weill Journal Article,1929 ( <> English )

*************************

After reading the German article I find it quite remarkable that knowledge and treatment of MWD for the next century after 1878 had hardly changed. To mollify any medics reading this file ; it was not until the 1970s that a more complete view of these syndromes began to emerge and from the 1990s an understanding of the background genetics emerged. These are very rare syndromes and it is to be appreciated that the ordinary family doctor would never in all likelihood come across anyone in his practise with these symptoms so to expect him to be aware of them is somewhat unreasonable. Even a regional skeletal specialist consultant may only come across a few such index cases in his working life. Of course he will probably see more followup related people with these conditions.
If any medics reading this file are aware of any pain management techniques for the painful versions of these sort of conditions your input would be appreciated.
http://www.bbc.co.uk/news/health-13068924 , april 2011. Dr Roger Newport, from the University of Nottingham, Mirage optical illusion , potentially for arthritic sufferers.
A couple of non-drug regime possible pain relief techniques. 1) T.E.N.S Transcutaneous Electrical Nerve Stimulator for alleviating pain. They are battery powered pocket sized units costing in UK about 80 pounds (130 USD). Produces electrical pulses to stick-on electrodes placed on the skin. Quote from an instruction manual " TENS devices are used for the relief and management of chronic (long term) intractable pain, post surgical and post traumatic pain problems".
2) Years ago I made a "kummerbund" out of some space-blanket material that completely nullified the pain of a bout of shingles around the waist. My doctor did not believe me when I made a followup visit and I said I had had no need for the prescription of heavy duty pain killers he had made out 2 weeks earlier and wasn't needed either. Someone told me heat was useful against shingles but I had no hot-water bottle but I did have some of this mylar ,aluminised plastic, space blanket. Space blanket material is found in camping/outdoor pursuit shops costing just a few dollars. It is the material seen wrapped around marathon runners at the end of a race - sweaty bodies I would have thought was the worst possible case for use but never mind. Don't place immediately to the skin is it conducts heat out and radiates rather than the intended radiating heat back into the body. For wrists cut a piece of space blanket about 12 inches by 18 inches and fold 6 times down to 12x3 inches. Wrap a strip of thin cloth around to enclose and seal the edges by sewing. Stick a pad of hook velcro at one end and a strip of felt velcro where the overlap is when wrapped around the wrist. It does rustle a bit.
3) For anyone finding typing difficult including people with RSI then computer voice to text /speech recognition software has improved a lot recently. Once trained to your own voice and in an otherwise quiet environment produces very few errors in transcription these days. A useful test phrase for any such software is if it can pick up the difference between spoken "recognise speech" and "wreck a nice beach" each spoken in some sort of context to make it more realistic.
4) Saw Jerry Lewis promoting this pain management device http://my.webmd.com/content/article/54/65247.htm?z=3064_00000_2010_00_05 for chronic back pain ( Medtronic / Tame the Pain / Pain Pacemaker , keywords ). Don't know if it is relevant to MWD if anyone wishes to research.
5) Some tips that may as well be in the general domain for sufferers of arthritis or anyone else with weak or painful wrists.
Techniques for opening "vacuum" sealed pickle or jam jars.
1) Puncture lid with an awl/ brad-awl and cover hole with a gummed label. or 2) Invert lid into a pan of just boiled hot water then turn upright and unscrew or 3) Bash the lid (on the edge) with a sharp tap from a piece of wood about 2-3 inches square and 9 inches long
6) New drug Tocilizumab, for the treatment of rheumatoid arthritis, may have some use for MWD.

To join the Wonky Wrist Club , e-mail

ncook246@gmail.co.....m  email address

A reserve email account is diverse9(commercial at)fastmail.fm. Please make emails plain text only , no more than 5KByte or 500 words. Anyone sending larger texts or attachments such as digital signatures, pictures etc will have them automatically deleted on the server. I will be totally unaware of this, all your email will be deleted - sorry, again blame the spammers.
Contact details are:- Nigel Cook, address is my business address (not related to the subject of this page in any way ). postal address:-
66 Ivy Rd
St Denys
Southampton
Hampshire
SO17 2JN
ENGLAND

I have no structure for corresponding to anyone by telephone or letter. My original email address used to be diverse@tcp.co.... but got spammed out of existance, later diverse2 and diverse9 before the commercial at @
Telephone number - the same number as it has been since 1988 but email is now the preferred method of contact so number deliberately not placed here. Far too many junk calls.
I devote a block of time each day to replying to emails.

Some DCS/MWD UK contact numbers / addresses

This help group is recognised by NHS Direct with annual snailmail validation on this page
NHS site

But erroneously "The following high quality evidence-based resources have been selected by our UK professional medical authors to answer your query on 'dyschondrosteosis and madelung wrist deformity' Patient Support Dyschondrosteosis and Madelung Wrist Deformity, 6 star rating "

For Dutch speakers and For Dutch speakers Wanneer u per email met Nederlandse lotgenoten in contact wil komen, mail dan naar Paula (met als onderwerp Madelung, Lerie-Weill of dyschondrosteosis) op mailto:PK_1976@hotmail.co.....m (verwijder de 5 puntjes tussen "co" en "m")

An MSN group set up by someone mentioned in these files MSN group - LWS/MWD
or http://leriweil.multiply.com/
Facebook
As it says in the URL One person's site "Kids with Madelungs "
or Archived "Kids with Madelung "

Bill Newman ,Manchester Dysplasias Research Group 0161 276 6506
Great Ormond St,Department of Clinical Genetics (SHOX Gene research)
30 Guilford Street,London,WC1N 1EH

Simon Thomas, WRGL Genetics, Salisbury District Hospital, Salisbury ,Wiltshire, SP2 8B , England

Details of one of the surgical corrective procedures
Another keyword for similar procedures is "orthofix"

Some DCS/MWD USA contact details
Dr. Pia Marttilla 1-800-444-9111 X 3078,Esoterix Endocrinology,LA, California.
Human SHOX gene database
SHOX Gene and DCS/MWD/LWS
Trial of growth hormone treatment for those with SHOX gene anomaly
A general collection of self-help groups for rare conditions
GeNeSIS - The Genetics and Neuroendocrinology of Short Stature International Study
A general site for dwarfism
A more technical article about MWD (registration is quick and straightforward as "general public" to obtain the full article )
Perhaps in the future everyone will look like this J Exp Zoolog B Mol Dev Evol. 2004 Mar 15;302(2):111-20. by Reinhard Stindl, Vienna
"In the absence of telomerase activity, telomeric DNA has been shown to shorten every time a cell divides. The concept of a mitotic clock based on the gradual erosion of telomeres is now generally accepted and has been confirmed in numerous plants and animals."


The origins genetically is probably a balanced reciprocal translocation of 2 genes technically 2;8(q32;p13) from American Journal of Medical Genetics 16:p589,1983. [That is the 32 section on the long, q, arm of the number 2 chromosome swapped with the 13 section of the short,p, arm of the number 8 chromosome. After derivation of the karyotype (separated and stained set of all the chromosomes) the long arm of chr 2 was obviously shortened and the short arm of chr 8 was obviously longer.] More recently located to part of the SHOX gene - Nature Genetics,p70,V19,May 1998. The SHOX gene is found in the Pseudo-autosomal regions (PAR1) of the sex chromosomes ,these PAR1 are adjacent to the ends (telomeres) of the p arms of the X and Y chromosomes. Although lying on the sex chromosomes they have a lot of similarity to genes that would appear on the non-sex, autosomal ,chromosomes hence pseudoautosomal. Suitable markers for the XY genes would seem to be DXYS6814,DXYS233,DXYS228 and DXYS234. Areas of interest are single C to T transition R195X,XY translocations p22,q12 and gene Xp22.3 or Yq11. From reference 17 "........haploinsufficiency of SHOX (Short stature homeobox- containing gene) is responsible for DCS,as affected families carried either large scale deletions (7 of 8 families) or a truncating mutation (1 family) of the gene..........
(haploinsuficiency relates to gene dosage ,if there is insufficient for the normal full transcription process). The absence of Madelung deformity in some short stature patients with SHOX mutations/ deletions (while others demonstrate both signs )remains an unexplained paradox. The variable expression of DCS features in individuals carrying terminal Xp deletions and XY unbalanced translocations similarly remains unexplained and might be due to either sex-chromosome- specific regulation or involvement of modifier genes".
From personal correspondence with a UK based researcher "....at present we do not identify the genetic cause in LWD (Leri-Weill Deformity) in a proportion of cases, but I know that other groups such as those of Gudrun Rappold in Heidelberg and Judith Ross in America are continuing to research this. When the gene for a condition is first discovered it is often the case that although it provides a genetic explanation for a proportion of people, it does not do so for everyone. As time goes by, different and more unusual genetic changes affecting the same gene are discovered. It is even possible that the condition could be caused by changes in genes other than SHOX. If some of the families who contact you are interested in research, I would suggest that they are first seen by their local Genetics department, and from here they can be put in touch with the centres who are continuing research into SHOX/ LWD."
Communication from Gudrun Rappold March 2006
Besides SHOX, there is evidence that a second gene is present in the human genome that, in its mutated form, causes an identical/ undistinguishable phenotype of Léri-Weill dyschondrosteosis. We are presently collecting families with Léri-Weill dyschondrosteosis that are not showing a SHOX defect in the coding or regulatory region in order to carry out a whole genome linkage analysis to pinpoint down this novel gene. Maybe you have a well established clinical/radiological diagnosis of "Léri-Weill dyschondrosteosis" but a SHOX mutation could not be confirmed and maybe there are also several affected members in your family. In this case I would be extremely interested in collaborating with you and I would be glad if you could contact us (.......@med.uni-heidelberg.de).
SHOX Human Short Stature Gene -Summary of Mutations
Exon Amino acid
change/stop position
Nuclear change Mutation type Phenotype
2
N77X
197-198delCG
Frameshift
LWS
2
E61X
G272T
Nonsense
LWS
2
V75X
272delG
Frameshift
LWS
2
X
GT-IVS-AG
Frameshift
LWS
3
Q112X
G425T
Nonsense
LWS
3
L132V
C485G
Missense
LWS
3
E149X
G536T
Nonsense
LWS
3
R153L
G549T
Missense
LWS
3
K181X
572insGT
Frameshift
LWS
4
R173C
C608T
Missense
LWS
5
R195X
C674T
Nonsense
ISS
5
R195X
C674T
Nonsense
LWS
5
Y199X
C688G
Nonsense
LWS
6
A224T
G761A
Missense
ISS
6
delH229-L232
776-787delC¥4aa
Deletion
ISS
Notes LWS - Leri-Weill Syndrome,ISS - Ideopathic Short Stature
Source reference [ 44 ] March 2002
Nothing so simple as one mutation leading to one clinical manifestation. The above recorded mutations occur in a region of less than 200 Kbases at the telomeric end of the short arm which is about 10 Mbases from telomere to centromere .

Some Pictures/Graphics from the following journal sources


But first an internet site with a rarity a non-medical picture of someone with MWD (Shelby's Corner, Stretch Magazine )
 MWD developement a
Graphics drawn from Xrays of developement of MWD from ages 2 years,4 years and 6 years compared to normal (on left) from reference 32
 MWD developement b
Graphics drawn from Xrays of developement of MWD from ages 8 years,10 years and 12 years compared to normal (on left) from reference 32
 MWD developement c
The above sequence of images show MWD of someone's right arm from age 3 to 60 taken from family snap shots. The image ,age 10 , shows radial curvature. The last 2 images are after successful surgery.
 MWD (non-bayonet)

Picture of the prominent ulna that the medics call "necropsy appearance" of MWD that didn't carry through the copying and scanning process very well from reference 6
 MWD (bayonet)
"Bayonet" form of MWD of someone in this group

 MWD (bayonet)
Close-up of the above

 MWD 2 cases
Two cases of differing MWD from reference 5 below

 MWD 7

A severe case of MWD before quasi-successful corrective surgery, post operation on corresponding right arm shown in family album sequence above.
 MWD
Case of MWD from 1938 reference 12 below also showing the foreshortening of forearms and "muscle-bound" or "popeye-arms" appearance.
 MWD bayonet type
"Bayonet Wrist" and Xrays in 2 perpendicular views showing the curved forearm bones and exaggerated space between leading to the "Popeye arm" or "muscle-bound" appearance from reference 16
 MWD bayonet type
Similar views with more pronounced curvature (hence muscular appearance) from reference 17

 mesomelia

A picture of someone with mesomelia and MWD from ref 11. Unless you know what you are looking for the difference between F forearm length and U upper arm length are not immediately obvious. She also (from the X rays but not too apparent in this picture ) has the curved bones of the forearm that give the "muscle-bound" or "popeye" appearance. Note also (which was not referred to in the article) the wide nasal bridge.
 mesomelia 2
Someone showing the effect in the lower leg from reference Journal of Bone and Joint Surgery, Vol 64B,No 3,p377,1982


Pictures of the mesomelia foreshortening in forearms and lower legs does not show too well but measuring of the bones does. The following is from 13 patients in one study, units are percentages compared to normal for that person's height in metres and age, not all data taken All are female except the last case.
height  |         ratio Radius/Humerus      |           ratio tibia/femur
and age | Right       Normal        Left    |     Right       Normal      Left
1.5,54  | 69            75          72.6    |      63           83
1.36,11 | 71.7          74          73.2    |      71           85
1.5,20  |                                   |      67           83          69
1.52,26 | 73.3          75          71.4    |     71.2          83
1.35,12 | 57.1          74          52.2    |     74            85          74
1.35,12 | 59.2          74          58.3    |     74            85          74
1.57,11 |               74          68.2    |                   85          77
1.57,14 | 70            73          72.5    |     76            83
1.55,13 |               73          72      |
1.47,36 | 70.2          75          69.5    |     84            83
 ?  ?   | 67.7          75          62.5    |
?  ,?   | 60.3          75          61.6    |
1.7 ,11 | 76.8          75                  |
from reference 8 below
From the Rappold book (ref 34 below) Anthropometric techniques
Upper Arm Length - Starting from the shoulder blade ,run finger laterally along ridge of scapula to tip of acromion (acromiale), and mark this point. Identify head of radius (caput radii or radiale) by paplpating space betwen humerus and radius at elbow,until you feel the head of radius, and mark this point. (when measuring make sure the marked points overlay the relevent bony part)
Forearm (lower arm ) length - With arm hanging loosely and palm facing forward, find styloid process of radius (processus styloideus or radial stylion ) - most prominent bony landmark at lateral wrist. Mark this point. Use previous upper arm mark .
Lower leg length (upper absent in this book) - Subject should be seated , with right ankle crossed over left knee. Find upper medial border of tibia (tibiale or condylus medialis),by running finger down patella until you reach tibial plateau,then move medially to edge of tibial plateau, and mark this spot. Find sphyrion tibiale (most distal point of tibia) by running finger upward from heel to point where tibia ends, a little distal to most prominent point of malleolus medialis (medial malleolus) and mark this point.

Medical Published Research in the Public Domain



1 American Journ. Dis Child. 132,1978,p1037 Xrays of an affected individual at age 12 and 45
2 Acta Radiol. Diag. 11,1971,p459 -4 generations with DCS
3 Clinical Pediatrics 1972,p281 -2 case studies,rather technical description
4 Italian J. Orth. Trauma. 1975,p141 3 generations,includes a tibial surgical intervention
5 Am. J. Roent. 1965,Vol 95/1,p178 -tabulated data focus on knee Xrays
6 J. Bone Joint Surgery V58B,p350 Aug 1976-Good overview with fairly simple terminology even if the title is wrong (Madelung Disease is a completely different condition).
7 J. Med. Genet. 1980,17,p41 -2 generations of family 4 affected out of 6 people
8 Radiology 93,1969,p1037 -Technical but clear X-rays and tabulated physiological data
9 Am. J. Dis.Child 120,1970,p329 -tabulated data of 8 patients
10 J. Pediatr. 68,No3,1966,p432 -Tabulated dimensional data and good differential comparison with related syndromes
11 Am. J. Dis .Child. November 1971-Representative photos of wrist and forearm appearance
12 Annals of Surgery 1938,p421 -17 pages lot of history,some graphics and good picture of bayonet wrists
13 Clin. Orthop 1976,May,No116,p24 -3 families also first published record of male to male transmission
14 Brit. J. Radiol. 47,1974,p634 -picture of male with "muscle-bound" forearm appearance
15 Nature Genetics V19,May 1998 p70-73 - Shox and DCS genetical analysis of 15 families up to 5 generations including a family of 82 over 5 generations with 43 affected individuals !
16 Nature Genetics V19,May 1998 p67-69 - Shox mutations in dyschondrosteosis, pictures and Xrays of "bayonet" MWD
17 American Journal of Medical Genetics 16:p589,1983 - 2;8(q32;p13) balanced reciprocal chromosome translocation and pictures of 4 family members showing Madelung wrists,mesomelia and cubitus valgas.
18 J. Med. Genetics 2001;38 :323 SHOX point mutations in dyschondrosteosis
The above periodicals were on the shelves of the teaching library of Southampton General Hospital with open public access.Similar collections of medical research periodicals are probably at other teaching hospitals in the UK. Holland and Tasmania has an open access policy for medical libraries but I don't know about other countries.
Two archaeological cases:
30 Nature vol 330,5 Nov 1987 Dwarfism in an adolescent from the Italian late Upper Palaeolithic (Age) - Mesomelic dwarfism, relative shortening of forearms and lower legs and also restricted elbow movement. Radio-carbon date 11,150 +/- 150 years, age at death about 17 years and accorded special funereal treatment. "one of the few caves in Italy with parietal art. Thus, the site was an important social and/or ritual centre, and it is clear from the limited number of burials in the cave that only certain members of the population were of the status necessary to be buried there."
31 Journal of Medical Genetics October 2000, 37(10)E27 A Case of Dyschondrosteosis from Roman Britain
31b International Journal of Osteoarchaeology Volume 18 Issue 4, Pages 431 - 437
Abstract, Osteological examination of a 9th-11th century skeleton from Black Gate Cemetery, Newcastle-upon-Tyne, reveals Madelung's deformity of both forearms and shortened stature due to reduced tibial length.
32 Text book : Congenital Deformities of the Hand and Forearm by H. Kelikian ,1974,chapter22 -18 pages including very clear drawings derived from Xrays showing developement of Madelung wrists every 2 years from 2 yearold to 12 yearold and description of surgical procedure to correct wrist deformity
34 In July 2002 Prof Dr Gudrun Rappold sent me a complimentary copy of her book published 2002
Understanding SHOX deficiency and its role in growth disorders: a reference guide
by Gudrun A Rappold,Judith L Ross,Rüdiger J Blaschke and Werner F Blum
Publisher TMG Healthcare Communications Ltd,62 Stert St,Abingdon,Oxfordshire OX14 3UQ,UK
ISBN 1 85113 265 1
A summary of the 130 page book :
Background to SHOX involvement in a number of stature syndromes - Leri-Weill,Madelung,Langer,Turner,Ideopathic Short and triple x (XXX).
Introduction to molecular genetics zeroing-in specifically to the SHOX gene. Introduction means introduction to practising endocrinologists and other physicians, for anyone else it would need further study to comprehend this sort of material. It covers the complex area going from details of the SHOX gene through transcription into biochemistry and on to the clinical expression.
There are two useful glossaries: clinical terms and molecular biology terms ,colour-code referenced throughout the book.
Appendices of genetic codes,codes for amino acids,pedigree analysis symbols, anthropometric techniques (to measure limb proportions etc) and anthropometric tables for ages 3 to 19 years for all the pertinent limb segments and list of abbreviations ( acronyms ).
40 Genome Research 1997 p1114 Man to Mouse-Lessons learned from the distal end of the Human X Chromosome
41 J Med Genet 1992 29 p455 Short Stature in a girl with a terminal Xp deletion distal to DXYS15...
42 J Med Genet 1999 36 p711 Loss of the SHOX gene associated with Leri-Weil ....
43 J of Clinical Endoc & Meta 2000 p245 Identification of Short Stature caused by SHOX defects and therapeutic effect of Recombinant Human Growth Hormone
44 J of Clinical Endoc & Metab 2002 p1402 Deletions of the Homeobox Gene SHOX are an important cause of growth failure in children with short stature.
45 Proc Nat Ac Sc March 1998 p2406 SHOT,a SHOX related homeobox gene...
46 Proc Nat Acad Sc Oct 1996 p10691 Cloning and characterization of four murine homeobox genes
47 J Med Genet 1995 32 p831 Short stature in a girl with partial monosomy of the pseudoautosomal region distal to DXYS15....
48 J of Clinical Endoc & Met 2001 p5674 Phenotypes associated with SHOX deficiency
49 J Med Genet 2001p323 SHOX point mutations in Dyschondrosteosis
50 Ann. Otol. Rhinol. Laryngol 112 (2003 ) p153 Congenital Conductive Hearing Loss in Dyschondrosteosis
51 J. Clin Endoc. Metab. ,Oct 2003, 88 (10) p4891 Auxology is a valuable instrument for the clinical diagnosis of SHOX Haploinsufficiency in school-age children with unexplained short stature.
52 Brit J. of Haematology 121, p375 Pseudosomal linkage of familial Hodkins Lymphoma : Molecular analysis of a unique family with Leri-Weill Dyschondrosteosis and H L.
A few useful sites are:-
An overview of the Medline accessible references
OMIM site
Medline Site
Medical Journals (abstracts only for us non-medics)
Background to a ,discontinued , court case where the mother was lying about her husband being the biological father to her daughter who had the appearance of MWD and her son who had the appearance of DCS. The husband had no family history of MWD or DCS but someone else did have such a family history.
MWD raised in a court case relating to a works injury
Newspaper story concerning DCS and growth hormone
I've grown 1cm since January Mar 9 2007 By Peter Henn A GIRL who suffers from a genetic disorder has won the right to NHS drugs that will help her grow. ... He added: “It’s good the PCT changed its mind after the YA’s campaign, but it was wrong to not give her treatment, especially when it has proven so effective.” South East Essex Primary Care Trust confirmed Chloe’s circumstances had changed, but said it could not speak about the case as it was a confidential matter. FACTBOX: *Leri-Weill Dyschondrosteosis (LWD) was first diagnosed by French neurologists Andre Leri and Jacques Weill. *It is a form of dwarfism marked by forearm and wrist deformities. *Sufferers of the syndrome are only expected to reach a maximum height of 140 cm. *Genotropin is a drug used to fight growth defects, and helps people with the problems reach a more normal height. A course of the drug costs the taxpayer between £122 and £278, but individual shots can range from £4.64 to £46.37.

For anyone interested this is the original of this file put on the internet on 31 January 1999, so 10 year anniversary in 2009 and still with the same URL surprisingly

There follows a summary of the above file in different languages

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A summary of this file
The method I used for doing medical research into MWD (Madelung Wrist Deformity) and DCS (Dyschondrosteosis). The technique is probably applicable to other rare medical conditions. Some other names for these conditions and associated medical terms. Genetic background to MWD and DCS Two recognizable people who may have the appearance of these conditions. Two simple tests that in conjunction with X-rays etc could lead to a diagnosis of MWD. Numerous (anonymized) personal stories of people with MWD or DCS who have contacted me. For anyone who would like to join this, closed group, mailing list my contact details are at the end of these personal stories. Some of the published research articles in the medical periodicals on MWD and DCS.

Un sommaire de ce dossier
La méthode que j'ai employée pour faire la recherche médicale dans MWD (défaut de forme de poignet de Madelung) et DCS (Dyschondrosteosis). La technique est probablement applicable à d'autres conditions médicales rares. Quelques autres noms pour ces conditions et limites médicales associées. Fond génétique à MWD et à DCS. Deux personnes fameuses qui pourrait avoir l'aspect / fond de ces conditions. Deux essais simples qu'en même temps que des rayons X etc.. pourrait developer à un diagnostic des histoires personnelles (anonymes) de MWD. Numerous des personnes avec MWD ou DCS qui m'ont contacté. N'importe qui voudrait joindre ceci, groupe fermé, expédiant la liste mes détails de contact sont à la fin de ces histoires personnelles. Certains des articles édités de recherches dans les périodiques médicaux sur MWD et DCS..

Een samenvatting van deze pagina
De methode, die ik gebruikte voor medisch onderzoek in MWD (Madelung Pols Afwijking) en DCS (Dyschondrosteosis). De techniek is vermoedelijk toepasbaar op andere ongewone medische aandoeningen. Sommige andere namen voor deze aandoeningen en geassocieerde medische termen. Genetische achtergrond bij Mwd en DCS. Twee mensen in het openbaar, die misschien de karakteristieken / achtergrond van deze aandoening bezitten. Twee eenvoudige testen die samen met RÖNTGENFOTO'S enz. zouden kunnen leiden tot een diagnose van MWD. Talrijke (geanonimiseerde) persoonlijke verhalen van mensen met MWD of DCS, die met mij contact op hebben genomen. Wie zich aan zou willen sluiten bij deze (gesloten) groep-emaillijst, kan contact met mij opnemen (zie aan het einde van deze persoonlijke verhalen voor contactgegevens). Sommige van de gepubliceerde onderzoeksartikelen in de medische tijdschriften over MWD en DCS.
Wanneer u per email met Nederlandse lotgenoten in contact wil komen, mail dan naar Paula (met als onderwerp Madelung, Lerie-Weill of dyschondrosteosis) op mailto:PK_1976@hotmail.co.....m (verwijder de 5 puntjes tussen "co" en "m")

Eine Zusammenfassung dieser Datei
Die Methode, die ich für das Tun der medizinischen Forschung in MWD (Handgelenkmißbildung Madelung) und in DCS (Dyschondrosteosis) verwendete. Die Technik ist vermutlich auf andere seltene medizinische Bedingungen anwendbar. Einige andere Namen für diese Bedingungen und dazugehörigen medizinischen Bezeichnungen. Genetischer Hintergrund zu MWD und zu DCS. Zwei Leute im allgemeinen Auge, das das Aussehen / den Hintergrund dieser Bedingungen haben konnte. Zwei einfache Tests, die in Verbindung mit Röntgenstrahlen usw. zu einer Diagnose (der anonymised) persönlichen Geschichten MWD. Numerous der Leute mit MWD oder DCS führen könnte, die mit mir in Verbindung getreten haben. Jedermann, das dieses verbinden möchte, geschlossene Gruppe, Liste sendend meine Kontaktdetails sind am Ende dieser persönlichen Geschichten. Einige der erschienenen Forschungsartikel in den medizinischen Zeitschriften auf MWD und DCS..

Un resumen de este fichero
El método que utilicé para hacer la investigación médica en MWD (deformidad de la muñeca de Madelung) y DCS (Dyschondrosteosis). La técnica es probablemente aplicable a otras condiciones médicas raras. Algunos otros nombres para estas condiciones y términos médicos asociados. Fondo genético a MWD y a DCS. Dos personas en el ojo público que pudo tener el aspecto / el fondo de estas condiciones. Dos pruebas simples que conjuntamente con radiografías el etc podría conducir a una diagnosis de las historias personales (anonymised) de MWD. Numerous de la gente con MWD o DCS que me han entrado en contacto con. Cualquier persona que quisiera ensamblar esto, grupo cerrado, enviando la lista mis detalles del contacto están en el final de estas historias personales. Algunos de los artículos publicados de la investigación en los periódicos médicos en MWD y DCS..

Um sumário desta lima
O método que eu me usei fazendo a pesquisa médica em MWD (deformity do pulso de Madelung) e em DCS (Dyschondrosteosis). A técnica é provavelmente aplicável a outras circunstâncias médicas raras. Alguns outros nomes para estes circunstâncias e termos médicos associados. Fundo genetic a MWD e a DCS. Dois povos no olho público que pôde ter a aparência / fundo destas circunstâncias. Dois testes simples a que conjuntamente com raios X etc. poderia conduzir a um diagnóstico de histórias pessoais (anonymised) de MWD. Numeroso dos povos com MWD ou DCS que me contataram. Qualquer um que gostaria de juntar este, grupo closed, enviando a lista meus detalhes do contato estão no fim destas histórias pessoais. Alguns dos artigos publicados da pesquisa nos periodicals médicos em MWD e em DCS..

Sammanfattning
Metoden som har använts för att söka efter medicinsk information om om Madelungs deformitet (MWD) samt Dyschondrosteos (DCS även kallat Leri-Weils syndrom), kan användas för att söka efter information om andra sjukdomar. (Vet du inte hur man lättast söker efter information i databaser kan du vända dig till närmaste bibliotek - de brukar ordna kurser i informationssökning som ofta är gratis.) Här nämns två offentliga personer som eventuellt kan tänkas ha dessa sjukdomar. Det beskrivs vidare två enkla tester som kan komplettera röntgenundersökning för att fastställa en diagnos av Madelungs deformitet. Genetisk bakgrund för Madelungs deformitet och dyskondrosteos. Personliga berättelser från personer som har kontaktat gruppen finns även publicerade på den här sidan, liksom referenser till publicerat material samt länkar till sajter/databaser där man kan söka efter mer information. De som vill komma i kontakt med den här slutna gruppen kan nå mig via adressen längst ner på sidan.

Un sommario di questo documento
Il metodo che ho usato per fare la ricerca medica su MWD (deformità del polso di Madelung) e su DCS (Dyschondrosteosis). La tecnica è probabilmente applicabile ad altre malattie rare. Altri nomi per queste malattie e termini medici associati. Priorità bassa genetica a MWD ed a DCS. Due persone famose che sembrano avere queste malattie. Due prove semplici che insieme con i raggi X ecc potrebbero condurre ad una diagnosi del MWD. Numerose storie anomine di persone con MWD o DCS che si sono messe in contatto con me. Chiunque voglia unirsi a questo gruppo chiuso, alla mailing list. I miei recapiti sono alla conclusione di queste storie personali. Alcuni degli articoli di ricerca pubblicati nei periodici medici su MWD e su DCS..

Hebrew

סיכום של הקובץ הזה בעברית השיטה שהשתמשתי בשביל לעשות מחקר רפואי בעניין MWD ( Madelung Wrist Deformity שורש היד של מאדאלאנג ) ו DCS ( דיסצ'ונדרוסטאוסיס ) היא טכניקה שקרוב לוודאי ניתן ליישם גם עבור ליקויים בריאותיים נדירים אחרים. ישנם כמה שמות נוספים לליקויים ולמונחים הרפואיים האלה. רקע גנטי לגבי MWD ו DCS : שתי אוכלוסיות שבעיני הציבור אולי יהיו בעלי ההופעה/ רקע של התנאים האלה. שני מבחנים פשוטים שביחד עם רנטגנים וכו' יכלו להוביל לדיאגנוזה של MWD . סיפורים אישיים של אנשים (בעילום שם) עם MWD או DCS שפנו אלי. לכל אחד שרוצה להצטרף לקבוצה הסגורה של רשימת הנמענים שברשותי, ישנם פרטי התקשרות אלי בסוף הסיפורים האישיים האלה. כמה מהמאמרים של המחקר על MWD וDCS שהתפרסמו בכתבי העת הרפואיים.

or Summary in Hebrew


Podsumowanie tego pliku
Metody uzywam do wykonania medycznego badania na wykrycie MWD (DEFORMACJA MADELUNGA NADGARSTKOW) i DCS (Dyschondrosteosis). Technika jest prawdopodobnie przydatna do wykrywania innych rzadkich medycznych wad. Niektore inne nazwy dla tych roznic i polaczenia medycznych terminow. Genetyczne tlo MWD i DCS. Dwie mozliwe do poznania osoby ktore moga miec ukazane takie warunki. Dwie proste proby ktore w polaczeniu z Przeswietleniem itp moga poprowadzic do diagnozy MWD. Liczne osobiste historie ludzi z MWD albo DCS ktore maja kontakt ze mna. Dla kogos kto chcialby wstapic do tej, zamknietej grupy, wyslijcie poczta opis moj kontakt i szczególy sa na koncu tych osobistych historii. Nieco publikowanych paragrafow na temat wykrywania MWD i DCS w medycznych czasopismach.

Et resume af denne fil/tekst
Den metode jeg har brugt til at lave den medicinske studie i Madelungs deformitet og Leri - Weill dyschondrosteose.
Teknikken er sikkert brugbar for søgning på andre sjældne medicinske tilstande/sygdomme.
Andre navne for disse sygdomme/tilstande og associerede medicinske benævnelser. Genetisk baggrund for Madelungs deformitet og Leri-Weill dyschondrosterose. To kendte mennesker som måske har disse tilstande og baggrunden for denne observation.
To simple test, som sammen med røntgenbilleder kan lede til en diagnose på Madelungs deformitet.
Flere anonyme personlige historier fra personer med Madelungs deformitet og Leri-Weill-dyschondrosterose, som har kontaktet mig. For alle som ønsker at blive medlem af denne lukkede gruppe, mailings-liste og mine kontaktdetaljer er efter disse personlige historier.
Nogle af de udgivede forskningsartikler fra tidsskrifter omhandlende Madelungs deformitet og Leri-Weill dyschondrosterose.



Apologies, ignore the following ridiculous situation. Because of SEO, search engines now only index the text appearing in browsers, it should properly be hidden from browsers. It is mainly keywords condensed out of the previous year sub-files to this file.

Unicode problems with foreign script Use XVI32 Hex editor to remove BOM characters [ Zero Width Non-Breaking Space (ZWNBSP) ] 255,256 / FEFF from the top of file and 00 intercharacter spaces. Convert Hex character codes to &#....; decimal codes that both browsers and Google Cached seem happy with. Copy text from Notepad or whatever to the text side of the XVI32 0D 0A is hex code for end of line. Thereafter for English updates save file as ANSI , not Unicode. To convert Hex text to decimal change line breaks to * and with no line wrap form single lines of text about 100 characters long, submit to Google search which returns then as &=....; code. Change * to 0D 0A madalin madaling discondrostis discondrosteosis madalins medalin medellin madellin medaling medalins madalin madalins madelin madeling madelins medelin medeling medelins medalin medalins madilin madiling madilins medilin mediling medilins madilin madilins medalin medaling medalins medalin medaling medalins medalin medalins medelin medeling medelins medelin medeling medelins medalin medalins medilin mediling medilins medilin mediling medilins medilin medilins midalin midaling midalins midalin midaling midalins midalin midalins midelin mideling midelins midelin mideling midelins midalin midalins midilin midiling midilins midilin midiling midilins midilin midilins mandalin mandaling mandalins mendalin mendaling mendalins mandalin mandalins mandelin mandeling mandelins mendelin mendeling mendelins mendalin mendalins mandilin mandiling mandilins mendilin mendiling mendilins mandilin mandilins mendalin mendaling mendalins mendalin mendaling mendalins mendalin mendalins mendelin mendeling mendelins mendelin mendeling mendelins mendalin mendalins mendilin mendiling mendilins mendilin mendiling mendilins mendilin mendilins mindalin mindaling mindalins mindalin mindaling mindalins mindalin mindalins mindelin mindeling mindelins mindelin mindeling mindelins mindalin mindalins mindilin mindiling mindilins mindilin mindiling mindilins mindilin mindilins mandolins mandolin mandoling madalungs madolin madoling madolins medolin medoling medolins madolin madolins madolin madoling madolins medolin medoling medolins medolin medolins madolin madoling madolins medolin medoling medolins madolin madolins medolin medoling medolins medolin medoling medolins medolin medolins medolin medoling medolins medolin medoling medolins medolin medolins medolin medoling medolins medolin medoling medolins medolin medolins midolin midoling midolins midolin midoling midolins midolin midolins midolin midoling midolins midolin midoling midolins midolin midolins midolin midoling midolins midolin midoling midolins midolin midolins mandolin mandoling mandolins mendolin mendoling mendolins mandolin mandolins mendolin mendoling mendolins mendolin mendoling mendolins mendolin mendolins mindolin mindoling mindolins mindolin mindoling mindolins mindolin mindolins mandolins
 Louise Robey fash5.jpg 200 x 270 pixels - 19k www.hotgossip.co.uk/ 99july/fash.html/fash5.jpg http://www.hotgossip.co.uk/99july/fash.html http://web.archive.org/web/20030125122359/http://hotgossip.co.uk/99july/images2/fash5.jpg ANYONE FINDING KEYWORDS HIGHLIGHTED IN THIS LIST between comment tags - they are condensed keywords from the year files dysch2001.htm dysch2002.htm dysch2003.htm dysch2004.htm dysch2005.htm 2001, 29 contacts plus 12 previously ^L in Sweden ^R in UK ^M in the UK ^M in Holland ^ R2 in the UK ^ T in Canada ^ L in Canada ^ D2 in e-m contact ^ C3 in the USA ^ S in the UK ^ D2 in the USA ^ S2 in the USA ^ K in the USA ^ B in New Zealand ^ J in the USA ^ R2 in the USA ^ M in Canada ^ C in Australia ^ L in Northern Ireland ^ A2 in the USA ^ M in Australia ^ M2 in Canada ^ W in the USA ^ L2 in Canada ^ H in the USA ^ S2 in the UK ^ S in New Zealand ^ J2 in the USA ^ S3 in the USA 2002, 23 contacts From V in the UK by contact by telephone From S4 in the USA in e-m contact From G in the UK in e-m contact From L in the USA in e-m contact From S5 in the USA in e-m contact From K2 in the USA in e-m contact From J3 in the USA in e-m contact From J4 in the USA in e-m contact From S6 in the USA in e-m contact From I in Holland in e-m contact From C4 in the USA in e-m contact From G in the USA in e-m contact From J5 in the USA in e-m contact From J6 in the USA in e-m contact From B in Australia in e-m contact From S in Australia in e-m contact From K3 in the USA in e-m contact From L2 in the USA in e-m contact From J7 in the USA in e-m contact From C5 in the USA in e-m contact From L in the UK in e-m contact From M3 in Canada in e-m contact From M4 in Canada in e-m contact Up to April 2003 USA D3 76 contacts 2003, 24 contacts S7 in the USA [ CL ] MWD M2 in the USA [ CL ] MWD and DCS A in Canada [ CL ] MWD T in the USA [ CL ] MWD K4 in the USA [ CL ] MWD A2 in Canada [ CL ] MWD and DCS A3 in Holland [ CL ] MWD A3 in the USA MWD M in Norway MWD D3 in the USA MWD M3 in the USA snail-mail MWD L in New Zealand [ CL ] MWD M4 in the USA [ CL ] MWD F in Chile MWD ? in England (NW) MWD + DCS N in the USA MWD + DCS M2 in Australia [ CL ] MWD + DCS L2 in the UK [ CL ] MWD + DCS D in Australia [ CL ] MWD E in the uk [ CL ] MWD A4 in the USA [ CL ] MWD M5 in Canada, MWD + DCS H in the UK, MWD S2 in Australia [ CL ] MWD 23 (24 - B in the uk , to 2005) contacts in 2004 M5 in the USA J in N Ireland L in Australia E in the USA H in the USA S2 in the UK C in the UK T in Australia UK telephone contact K5 in the USA J-? in ? A3 in Canada C2 in the UK A4 in Canada S4 in the UK K6 in the USA M-? in ? A5 in the USA K7 in the USA M2 in Holland C6 in the USA J2 in the UK ? in Peru, 20 Contacts in 2005 M6 in the USA J8 in the USA N in Israel P in uk? B2 in the USA D4 in the USA B in the UK ,Scotland T2 in Canada K8 in the USA C7 in the USA L3 in the USA C3 in the UK L3 in the UK H2 in the USA A6 in the USA P in the USA S8 in the USA S3 in Australia S9 in the USA A7 in the USA 19 contacts in 2006 S10 in the USA C4 in the UK I in Israel J9 in the USA T2 in Australia B in Brazil L in Denmark S11 in the USA J10 in the USA J in Holland A8 in the USA? T2 in the UK S12 in the USA S13 in the USA G2 in the USA J11 in the USA L3 in Canada From a medical director of Red Cross in _ _, Mexico In 2008 A10 in the USA? , A11 in the USA , B2 in the UK , D6 in the USA , J12 in the USA , K in the UK , L2 in Australia , M2 in the UK , M9 in the USA, (i R3 in the USA , S3 in the UK , T2 in the UK , ANYONE FINDING KEYWORDS HIGHLIGHTED IN THIS LIST between comment tags - they are condensed keywords from the year files dysch2001.htm dysch2002.htm dysch2003.htm dysch2004.htm dysch2005.htm dysch2006.htm Kienbock Disease, Lunatomalacia, Osteochondrosis of the Lunate Bone, ability, able, abnormality, abnormally, about, above, abreast, absolutley, accept, accepted, access, accident, accident, according, accordingly, account, accounts, accupuncture, accurate, ace, ache, aches, achievements, achondroplasia, acknowledge, acknowledged, acquainted, acquired, across, actions, activated, active, activities, activity, actual, actually, adapted, add, added, addition, additional, address, addressed, addresses, adequately, adjust, adjusted, adjustments, admitted, adopt, adopted, adress, adult, advance, advantage, advantages, advice, advised, advises, advising, aesthetic, affect, affected, affected, affecting, afflicted, africa, after, afternoon, afterwards, again, against, age, aged, agency, ago, agree, ahead, air, airforce, aked, align, alive, all, all, alleviate, alleviating, allot, allow, allowance, allowing, allows, alltime, almost, alone, along, alot, already, already, also, alterations, alternate, alternative, although, always, am, amazed, amazing, america, american, amongst, amount, amused, an, anabled, analyst, ancestors, ancestry, and, and/or, anecdote, auxology , angle, ankle, ankles, ankles, annoy, anomaly, another, answer, answers, ante-natal, anti-inflammatories, anti-inflammatory's, anymore, anyone, apparent, appear, appearance, appeared, appearence, appears, applied, applies, apply, appointment, appologize, appreciate, appreciated, approach, approx, april, architecturally, are, area, areas, aren't, arm, arms, arms, , arms, arose, around, arranged, arrived, art, arthritis, arthrodeses, arthroscopy, arthrosis, article, articles, , ashamed, aspect, aspect, aspects, assertain, assess, assessed, assistance, associated, assumed, assuming, assured, athletic, attempt, attended, attends, attention, attitude, august, aunt, auntie, aunts, australia, auto, autosomal, available, avid, avidly, avoid, awaiting, awards, aware, awareness, awkward, awlful, b, babies, baby, baby's, back, back-ache, background, backwards, badly, badminton, baffled, ball, bandage, bandages, bang, bar, barely, bars, base, baseball, based, basically, basicly, basis, basketball, bass, bath, battle, bayne, bayonet, beaking, bearable, bearing, became, because, become, becomes, becoming, bed, begging, begin, beginning, begun, behalf, being, belcher, belief, believe, believed, believing, below, benefit, bent, besides, best, better, between, beyond, big, bigger, biggest, bike, bilat, bilateral, bilaterial, birth, birth, bit, blank, bleeds, blessed, blessing, blessing, blood, blooded, blount, blount's, board, body, body, body's, boiling, bone, , bones, boots, boots...just, born, both, bother, bothered, bothering, bothers, bottom, bought, bounds, bout, bouts, bow, bowed, bowing, bowl, bowleggedness, bowling, box, boy, boyfriend, boys, brace, bracelets, braces, brake, break, , breaking, brilliant, bring, bringing, broke, broken, brother, brothers, building, bulging, bullied, bump, 'bump', bumps, burned, burning, business, busy, but, buying, by, c, c3, c4, c5, call, called, calming, calves, came, can, can, canada, canadian, cancelled, cancer, cannot, canoeing, care, career, careful, carefully, carpal, carpals, carpel, carpul, carried, carry, carrying, cartilage, case, cases, cast, casted, casts, cat, catalogues, catch, catches, cause, caused, causes, causing, celebrex, centred, certain, certainly, cervical, chain, chair, 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entries, entwined, equally, equipment, erratically, escalated, especially, essex, establish, esteem, etc, eternally, europe, evaluated, evaluation, evaluations, evidence, exact, exactly, examining, example, exams, except, excess, excessively, exchange, excited, exclusion, excuse, exercise, exercised, exercises, exostosis, expect, expecting, experience, experienced, experienceing, experiences, experiencing, experimental, expert, expertise, , experts, expla, explain, explaination, explained, explaining, explanation, explaning, exrays, extensions, extensior, extensive, extensively, extent, extra, 'extra, extra-bones, extreme, extremely, f, face, facility, facing, fact, facts, fair, fairly, faith, fall, fallen, falling, familiar, families, family, far, fascinated, fascinating, fashioned, fast, faster, fastest, fat, father, fathers, father's, fatigue, favorite, feb, feed, feel, feeling, feels, feet, fell, fellow, felt, female, females, fertility, few, fibers, fibrocartilagenous, fibromyalgia, fibromyalgia, fifth, fifty-eight, fight, fighting, figure, file, file/s, file}, filled, finally, find, finding, findings, fine, , fine, finger, fingers, finished, finland, first, firstly, fit, fits, five, fix, fixed, flat, flexibility, flexibilty, flexing, floppy, fluke, folks, folloup, follow, following, followup, follow-up, food, foot, football, for, forarms, force, forearm, forearms, foreshortened, forever, forget, forgot, form, formal, formation, formed, forth, fortunate, fortunately, forum, forward, forwards, fought, found, fourteen, fourteen-year-old, foward, fracture, fractured, frankly, fraternal, free, freely, french, frequent, frequently, friction, friday, friend, friends, from, front, frustrated, fsnet, ft, full, fun, function, functioning, fund, funny, further, fuse, fused, fusing, fusion, future, g, ganglion, gaurds, gearstick, gender, gene, genealogist, general, generally, generation, generations, genes, genetecist, genetic, geneticist, geneticists, genetics, geographical, get, getting, girl, girlfriend, girls, glad, gladly, glasses, gloves, glucosmine, go, god, going, golfer, gone, good, goodness, got, gotten, government, gov't, gp, grabbed, grade, grades, graduate, grand, grandchildren, granddaughter, grandfather, grandma, grandmother, grandparent, grandview, grasps, grateful, great, great, great-great-, greatly, greek, green's, grew, grip, gross, group, group, groups, grow, growing, grown, growth, guess, guide, guitar, guy, gym, gymnast, gymnastics, gymnasts, gyms, h, habit, had, had-surgeries, hahaha, hairline, half, halfback, half-sister, hampshire, hand, handed, handicaps, handle handles, hands, handstand, handstands, hang, hanging, hangs, happen, happened, happens, happy, hard, hardest, hate, hates, head, heads, heal, healed, health, 'healthier', healthy, hear, heard, hearing, heart, heart, heat, heavy, height, height, held, hello, hello, help, help...do, help, helped, helpful, helping, helps, help's, hemming, hendrix, her, her, here, heredetary, hereditary, heredity, heriditary, herited, hers, herself, he's, hi, hid, hide, hiding, high, high, highly, him, himself, hindered, hinged, hint, hip, hip...took, hipbone, hipbones, hips, hire, his, his/her, history, hit, ho, hold, holds, holland, home, hope, hopeful, hopefully, hopes, hoping, horizontal, horrendous, horrible, horrified, horse, horseback, hospital, hospital's, hot, hour, hours, how, however, huge, humor, hungary, hurt, hurting, hurts, husband, hydrocondroplasia, hyper, hypochondriac hypochondroplasia, hypoplastic, hysterectomy, i, icyhot, i'd, idea, ideas, identification, identified, ie, if, iherit, ilizarov, ilizarove, ill, i'll, im, i'm, image, imagine, imformation, immeasurable, immediate, immediately, immobility, impact, impacted, impaction, impaired, implications, important, impossible, impressed, impromptu, improper, improve, improved, improvement, in, in, inability, incapable, incase, inch, inches, incidence, include, include-both, including, inconsideration, increased, increasingly, incredible, incredibly, indeed, independent, index, individual, individuals, induced, infiltration, influence, info, information, information, informative, informed, inherit, inherited, inheriting, initial, initially, injecting, injections, injured, injury, inquire, inquiries, inquiring, insight, insisted, instance, instances, instead, instep, instructed, insurance, intend, intensified, intensive, interbreeding, interest, interested, interesting, interesting, interestingly, intermediate, intern, international, internet, intervention, into, intrigued, investigate, investigations, involved, involves, involving, inward, ireland, irritated, is, isnt, isn't, isolated, issue, issues, it, it, it, it...makes, it, italian, italy, items, jam, january, jar, jars, jimi, job, jobs, joined, joint, , joints, journal, journel, july, jumped, june, junior, just, jutted, , keep, keeps, kept, kettle, keyboard, keyboards, keys, keywords, kid, kidding, kids, kill, killers, kilos, kind, kindergarten, knee, knees, knew, knob, knobby, knobiness, know, know, knowing, knowledge, knowledgeable, known, knuckle, knuckles, labour, lack, landed, lap, lap...purses, large, last, lasted, lasts, lately, later, lawn, lead, learn, learned, learning, least, leaving, lectures, led, left, lefty, leg, legs, length, lengthen, leri, leri-weil, leri-weill, leri-weill's, leri-wells, less, lessen, lessons, let, lets, letter, letters, letting, levels, librarian, lie, life, life, life, lifestyle, lift, lifting, ligament, ligaments, lighter, like, like, liked, likely, likelyhood, liltle, limb, limit, limitations, limited, limp, limping, line, link, links, list, listening, literature, litle, little, little, live, lived, lives, living, local, located, london, long, longer, look, looked, looking, looks, loose, lose, losing, loss, lost, lot, lots, love, low, lower, luck, luckily, lucky, lump, lunate, lwd, lws, l-ws, lying, machine, madalung, made, madelung, -madelung, madelung, madelung`s, madelungs, madelung's, madelungs, madlungs, madulung, mail, mailing, main, mainly, maintaining, major, majority, make, makes, making, male, males, malformed, man, managed, managing, manchester, manifestation, manipulate, manner, manning, manual, manuals, many, march, marked, married, massage, massager, maternal, matter, matters, matured, may, maybe, md, md/lwd, mdw, me, me, me, meaning, means, meant, meantime, measured, measurements, measuring, mechanic, mechanism, med, medial, medially, medical , medical , medical, medication, medications, medications-, medicine, meds, meet, member, members, memory, mendel, mendelssohn, mention, mentioned, merles, meso-americans, mesomelia, message, messy, met metacarpal, metacarpals, metal, metaphyseal, metatarsal, meter, methods, methotrexate, mexican, mexico, mid, mid-20's, middle, might, migraines, mild, mild/moderate, milder, mildly, military, milk, mind, minded, mine, minidisk, minimal, minor, minute, minutes, miracle, miracles, mirror, misaligned, misdiagnosed, misplaced, mispronounced, misremembered, miss, miss-diagnosed, missed, misshapen, misshappen, missing, mission, mix, mixed, mixer, mobility, mom, moment, mom's, money, month, months, more, morning, morton, moscow, most, most, mostly, mother, mothers, mother's, moths, motion, motorcycles, move, movement, movment, mr, mri, m's, mths, much, much, much, mum, mums, muscle, muscles, muscular, music, must, mutated, mutation, mwd, mwd, mwd+dcs, nags, name, named, national, native, near, nearly, necessary, necessary, neck, need, needed, needle, needles, needless, needs, negative, neighbor, neither, neoprene, nephew, nerve, nerves, nerves, net, neuscense, never, new, news, next, nhs, nice , night, nightmare, 'nobble', non-painful, noone, nor, normal, normal, 'normal', normally, northern, norway, not, note, noted, notheless, nothing, nothing, noticable, noticably, noticeably, noticed, notices, noticible,, numb, number, numbness, numerous, 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useful, useless, using, usual, usually, uterine, utilize, v, valinda, valley, vara, various, vengeance, version, versus, vertical, very, veteran, via, visible, visit, visited, voice, volleyball, volleyball, w, w/, wait, 'wait, waiting, waitress, wake, waking, walk, walk-by, walking, wall, wanna, want, wanted, wants, war, warm, was, wasn't, wasp, watch, watches, water, water-ski, way, way, ways, wd, we, weak, weakness, weakness', wear, wearing, weather, web, webpage, web-page, website, website, web-site, wedging, week, weeks, weigh, weight, weights, weill, -weill, weird, welcome, weld, well, well, wellbeing, went, were, we're, wet, what, what, what, whatever, what's, wheelchair, when, where, whether, which, while, whiplash, white, who, whole, whom, who've, why, why, wide, wife, will, willing, win, wise, wish, wists/, witch, with, within, without, wobbly, woke, woman, women, wonder, wondered, wonderful, wondering, won't, wood, word, words, wore, work, work, worked, workforce, working, working, workload, workman's, world, worried, worries, worry, worse, worse, worsen, worsened, worsens, worst, worst, worth, would, wouldnt, wouldn't, wow, wrapped, wrestling, wrist, wrist/forearms, wrist, wristbands, wrists, wrists, wrist's, wrists, write, writing, writst, written, wrong, wrote, wrsit, x, xray, x-ray, x-rayed, xrays, x-rays, x-ray's, x-rays, , -xxx-, year, yearly, year-old, years, yes, yesterday, yet, yikes, you, you, you'd, young, younger, youngest, your, you're, yours, yourself, you've, yr, yrs, yugoslavia, zealand, ANYONE FINDING KEYWORDS HIGHLIGHTED IN THIS LIST between comment tags - they are condensed keywords from the year files dysch2001.htm dysch2002.htm dysch2003.htm dysch2004.htm dysch2005.htm Madelung Deformity. embarassed short arms recommended doctor who specializes tentative 'diagnosis' MWD DCS physical appearence, information physical appearence Cortozone injections ( Trauma induced ) grandfather apparently my appearence is much more noticable. madelungs deformity significant change pain every day didnt realise really apprehensive Ilazorov frame advice or contribution appointment discuss different types of operations that have been tried before. wretched deformity. surgery was not the way to go. best surgeon ulna nob the bone (wrist to elbow) to protect the bone. This arm responded gets sore but the pain wrist nob. The wrist can now flex. surgeries First surgery massive bone plate didn't stay attached. pelvis bone new plate installed. come loose Cannot lift fingers like being in a fist position and middle 2 fingers will not straighten out. remove the plate, take a tendon reconnect the tendon. tendon to those fingers ruptured due to riding over the plate "the looks of the arm." "just a little piece" of the pelvis or hipbone. arm was very bowed and the bowed bone look better? a severe case. shape influence such a difficult decision... lived in casts The casts go fingers to shoulder. great grandmother protruded bone at her wrist. aunt remembered women were very short and had the heavy wrists. unknown shared common ancestor great great-grandmother good condition surgeries on my arms. grandmother's Mom and Grandmother Grandma's Mom stuck a needle into the bone to drain the fluid. great-aunt, protruding bone s a slight curvature. curvatures. discuss my arm looking at my arms. cannot be fixed. acknowledge my arms were different. show them your arms." Mom or g-mom's arms. arms hurt. grand-daughter has the protruding bone, but no pain or curvature. size of others wrists have very heavy wrists and big hands. - removed the plate. - shaved down the ulna bone. - the ruptured tendons could be repaired, so....he reattached them to the fingers. - he split the scar tissue in the wrist, tendon repair area, scar tissue and never can come undone. - next, he moved the wrist back in line as it was dropping down and attached it so maybe with luck it can't come loose and drop down again. "reverse kleinert" splint. angles have all changed. reconnect the severed tendons to my fingers, slowly stretch the tendons out and make the fingers work. raise my fingers up, just trying to lower them to the flat part of the cast. she molded the cast to me, then attached the arched bar across the top and started connecting the fingers into the little slings for each one. ran into a problem when the little finger refused to stay in line. it tends to stray all over the place without my knowledge. roaming fingers! the therapist cast loose piece of cast below it. slings are a piece of suede lay flat on the cast. reconnect the tendons fingers as they had all ruptured. tendons to the fingers bone mass in the wrist. anti-inflammatory called norgesic medication, kidney failure tylenol 3's with codeine kidney specialist. using pain killers and surgery. rapid decline. orthopedic surgeon, ulna bones back, nothing that can be done definite good outcome. a growth hormone problem x-rayed orthapedic surgeon not finished growing, an Australian family history or short arm stature being disabled vacuuming. american female slightly nervous hearing that i have a deformity mild carpal tunnel syndrome x-rays. my pain strength in my left wrist. loss of strength overwhelming pain t follow up appointment madelung's in my left hand. have bilateral madelung's! pain came overusage soft splint for my wrist comfortable to sleep in B-6 vitamins. daughter's madelung Each generation has progressively worsened. live with increased pain refuse to allow the pain to dictate my life. range of motion is severely limited, , you improvise. good percentage of positive results. physicians stopped growing- pop my wrists, wear supports, etc. complete simple tasks. surgery despite pain, positive feedback dwarfed- geographical data. Norway. primarily frustrated lack of options to fix my wrists, physically capable of, pain is a side factor left hand is numb as I type. to be worsening (especially in range of motion), more precautions not to overuse them. quitting my display job. righthanded right hand is worse emedicine data specialists for advice regresses by generation, progressively gotten worse. scan bilateral talipes was diagnosed, very detailed scan a relatively short femur. paediatrician shortening of the long bones on both his arms and his legs. His wrists have a 'broken' look and the middle finger on his right hand appears to have a knuckle, unable to bend it. consultant clinical genticist in plaster casts for treatment of the talipes definately abnormal finding upper limbs ulnar deviation of the hands at the wrists relative shortening of the ulna in relation to the radius on both forearms. There was aloso incurving of the little fingers - clinodactyly. light shortening of the humeri, which are the bones in the arm between shoulder and elbow, and femori, whch are the thighbones. shortening of the forearms more noticeable in the unlae than in the radii." long-term future age-group husband was only diagnosed doctors to listen to him. Leri Weil and Madelung along with the short stature. run in his family the short stature, and the Madelung The blood results man's shox test Leri Weil and Madelung along with the short stature. high frequencies) was just a curse - all left-handed. Madelungs' "straighten her wrist". believes our deformity it is not something to be discussed deformity throughout her body, and is very small for her age and frail. Husband of wheelchair-bound wife with arthritis-like problem really large wrist bones orthopedic dr for a shoulder problem. I held my arms out. called Madalins Deformity mother's family biological family history. madalungs deformity. I feel powereless bilateral madelung wrists gradually increased in size and the pain has been unbearable at times. left is more abnormal vein is so prominent anti inflamatories and pain killers Dihyracodine. a hand surgeon shortening the bone and putting in a plate or removing the bone. e removing the bone people suffering their wrist clicking which is more painful, Madelungs excrutiating pain daily. growing pains. surgery (hip bone) back the motion l cause me pain. stress damage and arthritis elbows down. My fingers are constantly swollen and my joints(fingers) are turning purple. diseases worse crippling pain knees and back have always bothered me too. symptoms are related gymnasts wrist deformity similar symptoms boney lump at the end of her ulna sticks gymnastics large calves in proportion to our size. Does it sound to you that she might have it? Does every one who has it develop pain? will she be able to carry on with gymnastics,both imeadiatly before she sees the G.P. and repeated microtrauma Madelungs deformity madelungs wrist deformity. sprained my wrist and x-rays experiencing severe pain baby finger and shoot up to my elbow, numbness in both hands, fumbling things and dropping things. y wrists were permanently dislocated. golfers elbow. Orthopedic Dr. severe childhood injury X-rays of the wrist e lack of ulna joint). , wear & tear on a sub-optimal joint. The lag between trauma and condition developed 'backwards', the radius stopped growing prematurely (chipped growth plate we think) and the ulna continued Ulna protruded severly 'simple' excision of the (distal) third of the ulna. The floating bone fragment post-op calcification,severed end of the ulna proper range of motion post-op wrist injury or wrist pain d tendonitis cortisol injections orthopedic hand surgeon repeatative motion all day. ganglion cysts arthritis, carpal tunnel syndrome - to over-worked wrists almost unbearable. semi-fist position using my thumbs and point fingers. . My spine feels bruised massage therapy experience such symptoms. Sweden e severe back pain as well .. diagnosed with scoliosis of the spine orthopedic says .. Holland. Dyschondrosteosis. e I had Leri-weil.. Leri-weil, I've got a family member getting pain. cut the longer bone back straighten the bowed bone. visibly crooked or bowed odd angle, pain in my arms and they are very weak. cannot lift something dislocating my elbow. Neurofibromatosis. Misshapen bones website address by my doctors. carry out some research at the time, breaking my arms and lengthening them with metal rods. are a third shorter than everyone else. or archived as it keeps disappearing "Kids with Madelung "
h no pain in my wrists having short arms is: school - children are very honest on what they see. Buying clothes, like jumpers, shirts exercise and weight lifting family history, my older sister Great Aunt, picture she had it in her legs future children located the gene and can sup remove it a lot of pain breaking the bones rods and stretching them straight. both arms and both legs. a growth spurt lot of pain involved. He is short for his age, sucess stories Leri-Weil pain anymore. I have madelungs and I was curious to know if you would I'd be willing to give you some constructive critisism, if you're inclined of a similar problem in Australia which was helped by orthopedist acts genetically addicted to Dihyracodine advised me not to discuss it with my gp and has arms are shorter bad feet with platfus (pes planus, flat foot ) bilateral wrist pain birth defect Both carry high risks both Madelungs and dyschondrosteosis both my wrists were abnormal both wrists brother shows some signs calcified since i have limited movement in that wrist comes from my fathers side condition for years without knowing I had it conducted both tests in the office consultation correct diagnosis corrective surgery on my left arm coughing up blood created a prosthetic daughter had weird shaped wrists deformed right arm diagnosed as bilateral madelung wrists diagnosed at a young age diagnosed prior to the onset of pain diagnosed with madelung diagnosed with Madelung's Deformity of her left wrist dianosied discuss my condition disenchanted and overwhelmed doctor had never heard of the deformity doctor knows what to test me for does not want to engage in any competitive sport doing typing at school even shorter forearm experience with the ilizarov technique experiencing extreem pain and discomfort in my anles extensive research on various genetic wrist deformities family being normal height finally have a diagnosis finger bones are fused For your information and individual research, I wanted to let you know that Tyelonel for the pain in my wrists, local health center, diagnosed as tendinitis... Physicians Assistant second opinion, soo persistant (stubborn?)...my right wrist was and still is worse than my left. corrective surgery performed on my right wrist when I was 16 years old. 50/50 chance of the surgery Mobility and rotation did improve, cut off the end of my Ulna, far outgrew my Radius, twisted causing a severe V trench, metacarpals were getting "crunched" in. An arthography test breakage of cartilage, but wrist brace.. tendons and ligaments pain killers/medication, ibriprofin severely wrenched for some bayonet type of MWD, fat forearm. protruding Ulna I am also very short (5 foot, 1 inch), very short limbs, .a wide nose. :-) good hearing, hearing test "pidgeon-toed" feet. wear braces as a baby, knee and back problems. bones are thick and akward, y stocky, and my joints hurt often. unusually short Ulna. "preventative maintenance" madelungs deformity in the wrist, gymnast didn't heal properly, small for her age measured with all joints measuring different, growth hormone growth a boost,severe problems with her knees, hyperextended knees physio. Modelung deformity and leri Weill syndrome DNA (SHOX) test, deformity by Ultra Sound pregnancy? Adult Idiopathic Scoliosis multiple surgeries, fusions with hardware and reconstructions and revisions NYC Orthopedic Doctor hand Specialist wrist arthogram impacted ulnar. genetic bone deformity as my scoliosis My knees are lacking cartilage from the shifting of my spine and hips and I have had several knee arthroscopy's. Hand Specialist in (called Darrah Procedure?) screw, rods, a cage at S-1, mesh between the two removed ribs, bone dowels and heaven knows what else. carpal tunnel or just arthritus, rare genetic bumped them. Ulna was quite prominent. bone fused no movement in my wrist whatsoever. Orthaepedic Specialist. ganglions?? bilateral Madelung's deformity with a blocked supination Operation: Osteotomy bone graft and T plate fixation left radius. Osteotomy and six hole plate left ulna. Incision: Longitudinal incision over the dorsal ulnar aspect of the left ulna. Distal half of forearm. Second longitudinal incision on the radio-palmar aspect of the distal third of the radius.
Prcedure: Through the dorsal incision the incision was carried down between EDM and ECU. An osteotomy of the shaft of the ulna was performed three inches from the ulna head. A one centimetre block of ulna was removed. Through the radial incision an osteotomy was performed about one inch proximal to the radio-carpal joint. The dorsal cortex was kept in continuity. An extension ostetomy was performed. Part of the excised ulna block was fashioned into a wedge shape to provide a dorsi-flexion osteotomy of about six millimetres on the palmar aspect wedged to fit into the opening osteotomy. The osteotomy site was held with a T shaped plate with two holes proximal to the osteotomy site and three holes in the trnsverse part of the plate distally. distal part of the ulna palmar osteotomy effect. A six hole DCP compression plate osteotomy site. passive supination was to 60degrees and pronation full. There was 70degrees of flexion and 70degrees of extension. Tourniquet was let down, haemostasis obtained. Copious washout, closure to fat and subcuticular to skin. Wounds were dressed and a forearm plaster splint applied. Indications: Madelung's deformity right wrist.
Operation: Right radial opening wedge osteotomy and shortening osteotomy of right ulna. Procedure: Right upper limb exsanguinated tourniquet applied under general anaesthetic. The ulna was approached along its subcataneous border and 6mm trapezoid removed such that slight flexion would be imparted to the ulna. The radius was then approached from the volar aspect through the bed of the FCR tendon. The pronator quadratus was lifted from the radial aspect of the radius to expose the proximal radius. A three hole T plate was the fixed to the bone in slight ulna angulation so that the deformity would be reduced on evetual fixation. Osteotomy was the performed at the radius leaving a dorsal-radial hinge and the bone jacked out 4mm at the ulna volar side using the graft from the ulna. Fixation was then completed using a six hole small fragment DCP on the ulna. Wounds closed in layers after haemostasis obtained with 2.0 Proline to the skin, standard dressing. Interposition arthroplasty of right distal ulna. Procedure: Under GA tourniquet control the previous incision was opened. DCP plate, screws and a Kirschner wire were removed. Approximately 1cm of the ulna was resected where the sudoarthrosis had reformed. The flexor surface of the ulna was stripped of periosteum and this flap folded over the proximal ulna through drill holes covering the bone end. Extensor carpi ulnaris was clipped longitudinally, rolled to an anchovy and secured to the distal portion of the ulan with drill holes with 4.0 Ticron and 3.0 Vicryl. Assessment: Rotation then showed 70degrees of passive supination, full pronation. The dorsal branch of the ulna nerve was identified and traced distally. Haemostasis was achieved, the wounds were washed out with saline and closure performed over a Redivac drain with 3.0 Vicryl. "anchovy procedure" rolling up of tendons as a spacer ) limestone (calcium) beguile in blood very. children's health centre I am anesthesiologist and pain specialist (Brasil). intra-uterine life, your Ultrasound present "shortning of long bones" (umero femur ulna radio tibia peroneo) Your cariotic is 46,X,add(x) (p22.3) - SHOX gen. The geneticist (ulnar desviation.....). Denmark Growth hormones? two half-siblings. prominent distal ulna")lumps on my wrists,long sleeve shirts, anomally I unacceptable protruding/prominent ulna ends, "ball-type" features (protruding ulna) cosmetic anomolies corrective surgery on my wrists, personal experiences with Madelung's Deformity. MD as a "symptom" of LW/DCS. carrying heavy groceries) 'wrong' movements, layman's language? geneticist. 50/ 50 chance of passing it on. bloods were taken for the DNA and SHOX genes testing. worrried sick of passing this on. bones in his lower arm were reversed. lower arm too My wrist is big and painful reversed bone theory fingers are starting to freeze up. hands were very crooked monster movie. hands became so bad. "funny wrists" gunea pig technical jargon miscarrying endocrinologist that the Hodgkins ( which my sister also had) and the Madulungs( which my mother also shows signs of) are linked in a shox mutation. IVF PGD big calves! Florida. Madelungs Deformity My arms are noticably 2 different lengths. 3D x-rays. full mobility Canada Mexico orthopedics surgeon friend whom had similiar shaped wrists functionality is very good genetic error good candidate for surgery gradually increased in size grandparents are short, but not pathologically great surgeon guinea pig hard to keep job because my wrist is constantly sore have had anti inflamatories and pain killers but they are no use helped a little bit but i still have problems Hi, my name is B_ from Hi, my name is S _ from Sydney Australia. My 11 year old niece as just been homeopathy, as I am a trained homeopath huge decision to operate hurt beyond description and take pain meds I am a 25 year old female who has had I am considering surgery I came across your site while browsing for info recently. I like your site. I cannot lift things over 2 kg's I could not turn my wrist palm up to throw under handed I do not feel like an alien I drop lots of things I have just been (original contact in mid 2004 ) I have never known exactly what is wrong or if there is a name for this I noticed she has had chubby wrists from birth I thought you might want the information for your site. If you have I tried reading and understanding your article on DCSMWD but got lost I want more info I would welcome some support i'm left handed also immature skeletal system immediate famly impact her teen life In short - at present we don't know of anyone else with MWD. increasingly bothersome as I age I've just finished reading your site, I came upon it in my search for a just been diagnosed with Madelung Deformity just dx with this condition lack of expertise lack of knowledge I have encountered thus far in the medical profession large calves and have a stocky bone structure left hand is smaller than the right and her arm is 2.5 cm shorter legs situation is also partly a deformity Leri Weill is prevalent Leri Weill sufferers Leri Weill sufferers Leri Weill syndrome Leri Weill syndrome and as a part of my Leri Weill, madelungs deformity limited movement of both wrists vertically and horizontally limited wrist movement Madelung appearance Madelung Deformity madelung deformity with knobs on Madelungs Madelung's Deformity Madelungs deformity since birth Madelung's Disease making a conscious effort to use my left Manhattan manifestation Many Thanks for the good Work you are doing.
medical jargon metal plate about 5 inches attached to my ulna micro-surgery mimics the DRUJ (distal radio ulnar joint) mother had this affliction movement tests movement was a little odd My 8 year old daughter has my arm hung by my side at an odd angle My daughter E, now 15, was my elbow touching my side and my forearm facing upwards my left is more abnormal My name is H - I am 33 years old and have had problems with my wrist My parents didn't notice my My wrists are so painful at the moment N1L,N1R, P1 and P2, although they were not measured never go away and it can never be fixed never noticed anything else abnormal New Mexico USA no pain associated with her wrists normal activities not able to extend her arm fully with her palm up not exactly a giant not make me much taller it would prevent any pain not pathologically shorter not showing signs of further growth nothing to worry about numb after prolonged use of hands off sick for a month often wears options ran out orthapedic surgeon's words Orthopadist Orthopaedist orthopedic surgeon osteo arthritis and poly neuropathy in my legs and arms paediatric orthapedic surgeons pain is tolerable pain would be worse after sugery pains in my leg Pediatric Orthopedist perform a genetic test physical signs of the abnormalities physician in NYC prevent pain in Leri Weill producing more with this affliction progression of the deformity between the 8-15 age period progressive progressiveness of this deformity pure aesthetic reasons putting in a plate or removing the bone questioning radiologist had heard of Madelung Deformity radiology pictures on your site radiology techincian also had never heard of the deformity recommend surgury relatively short removing the bone reports of people suffering from their wrist clicking reset the bone giving it a straighter appearance and to make me same problems scanned see a hand surgeon in see even one person who had this self dianosed myself severly in both wrists short arms and legs, but not excessively so shortening the bone similarities between this woman's wrists and my daughter's wrists situation has fully stabilized specialist about my wrist as well due to pain ssa disability still not operated on still remains in pain stomach problems from pain killers surgeon in Kentucky Surveillance Specialist, Birth Defect Monitoring Division, _ Dept. of State Health Services, USA testimonies I have read on this site Thak you so much for all the information on your web site. You've put in so Thank you for your work on this site. My name is M and I am from _ , New York. My daughter, who is 13 was recently diagnosed with this deformity and surgery has been recommended by a Thanks The 14yo daughter of a friend has just been diagnosed with three surgeries on her arms tossing a ball back and forth treated with growth hormone treatment treatment would prevent any discomfort as I got older try to correct the problem unbearable at times various skeletal deformities vein is so prominent very limited range of motion very uneasy feeling virtually no use with my right wrist visibly shorter (5feet) Work carried out a work station assessment wrist area year later my body rejected the plate "wrist deformity". exact same wrists having pain in my wrists, on and off, since I weird shape of my wrists deformity has gradually increased "just the way it is" further medical help. pain in one of my thumbs and my little finger. stress ball to strengthen my joints. The pain started to spread throughout both of my hands. wondering if Madelungs can cause pain in finger joints? I keep getting needle-like pain in my fingers and knuckles. Sometimes they feel a bit hot and swollen. shorter than they should be measurements your forearms should be in length compared to your upper arms? weird looking wrists. actual condition pain in my hands kept me awake last night. trouble gripping a pen properly to write. showing my wrists are disclocated. genetic disorder -genetic specialist. orthopaedic doctor. misaligned bones may be trapping a nerve complaining of a sore wrist diagnosed madelungs. As she suffers from a lot of pain and has limited . Kapanje procedure? linked to Turners Syndrome pre eclampsia breathing difficulties and the upper back pain, do you think either quite small in stature dwarfism bilateral madelung's deformity degenerative changes my bones to shorten it and "shaved" a bit off the one that sticks up.hassle of always covering my arms. hand/wrist surgeon. stunted my growth (I am 5'2") close in wrists and ankles. limited mobility (not being able to turn to look at a watch, etc.), prescribed surgery to fix the problem. Pinned together and casted no physical therapy and I have multiple scars and puffiness bewildered surgeon. an inflammatory drug - hereditary condition, pediatric orthos to get x-rayed. So far, my 9 year old daughter appears my extended family. both heads of the ulna removed n my dominant arm. Range of motion has markedly decreased, with much more bony prominence on underside of my arm. I often have dull aching in the whole joint, very quick sharp pain, fleeting using the computer mouse for any length of time. Fatigue sets in very quickly. X-rays deny presence of arthritis, EMGs deny carpal tunnel and other nerve compression syndromes. A local orthopedic "hand man" no appreciation of slow progressive changes in past few years."crooked arms".. told she had rickets. (Boy, was that wrong!) Leri-Weil Dyschondrosteosis, with pain but none of these seem to make any difference. Daily tasks like washing, drying hair, washing dishes, making meals and driving shortened the outside bone petite side. leg bones appear to be shaped funny. "weird" wrist bones she is not as affected as I am, she has the very thick calves (my fathers sister) (severe or not) we do not all carry the gene or pass that gene (suarve kapanji) on both arms but my right arm _ in Los Gatos, Calif. performed surgery on my worst 153 but no bones funny structure ( no madelung no genou varum ). osteotomie. osteotomy. wore a wrist brace, playing golf my left wrist began to hurt much worse ulnar knobble on my wrist. The pain is sporadic. left knobble (the bone on top of my wrist) at end of the ulnar is protruding much more and is farther back. My right ulnar knobble is also a bit higher than before but not farther back. I've had protruding ulnar knobbles but never as unusual until now arthritis, osteoporosis or ligament tear or from being in menopause but nothing matched up as close as MWD. my daughter has inherited the conditiona denervation operating he had moved a full skeletal x rays my left wrist is starting to hurt a bit my baby boy does present with LWD kids with the same condition metacarpals had fallen lower into the wrist fraternal great grandmother, Cherokee Indian and German, freak accident stocky build, consaguinous theory arm about nearly an inch shorter than the other a CVS testing and can not walk any more. I can touch both my wrists with my middle and rings fingers. within the normal range change /SHOX gene. artrossis unilaterlally, and I am bilateral. arms, legs & buttocks. My upper arms always looked muscly, though they weren't! arms. arthritis in both arms Orthopedic my short stature, available procedures. SHOX gene defect wrist issues.my grandfather father very short medical advice children carry the gene. madelung syndrome, my Dad's Dad had the condition. CVS forearms are very short and curved, with a prominant wrist bone. gene in the baby genou varum but no wrist sign. gneticien. mesomelic dysplasia viable diagnosis. have full motion in my wrist seek medical attention for it a final diagnosis ler-weill syndrome. ulnar knobble is protruding hyperlaxite of the joint and the genetics behind Madelung's Madelung's deformity, cousin (who is a fraternal twin) Geneticist Madelung's, I have inherited collecting data on this, lifting, opening jars, my family tree passing it down? radiologist shortened bone, and motion was slightly different MWD as a birth defect, ligament. lower legs bow outward. Madelungs looked broken not wear short sleeves for a long time), incestuous origin? odd "deformity". surgeon just move the tendon of the knee. capping the pain in both wrists. I had reconstructive surgery on both wrists, rare condition ft wrist alternates between numbness and pain damage to the tendon due to years of scrapping against the rough severe pain in my right arm and moderate pain in my left arm, short arms & legs, long torso, & stocky stuck out more than the average persons surgery and to just learn to live with it. surgurey for my very short legs, symptomatic of some genetic disorders small stature with skeletal deformation. a hematologist, and 3 sports medicine physicians bobble appearance, on my left arm, medical profession geneticien in othopedic or geneticien to have fusion, effect exercise/general use of my wrist, a proffesseur orthopedic Leri Weills with Madelung diagnosed ulnar bone as its rubbing on my Radius and casuing a groove and more pain. ulnar bone. up with a fracture of my 2nd metacarpal. x ray about my skeletal and I was _ collagen is genetic aspect of the deformity denervation proportional to hand and forearm strength, bone was cut down a ANYONE FINDING KEYWORDS HIGHLIGHTED IN THIS LIST between comment tags - they are condensed keywords from the year files dysch2001.htm dysch2002.htm dysch2003.htm dysch2004.htm dysch2005.htm
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